Paroxysmal Nocturnal Hemoglobinuria (PNH) is extraordinarily rare and qualified hematologists/oncologists with expertise in PNH are equally hard to find. Fortunately, AAMDSIF has secured Dr. Carlos De Castro (Duke University School of Medicine) to provide an update on how to best manage PNH from the patient's perspective along with insight into new treatment options that are in the pipeline that may provide some hope for PNH patients experiencing complications with their disease.