News and Treatment Updates

Here's where you'll find a regularly updated, broad range of articles written by the AAMDSIF team, allied health organizations and news organizations. By staying well-informed, patients and families are practicing a form of self-support that will help them be more effective self-advocates when engaging with health care providers.

Immunotherapeutic targeting of calreticulin mutant myeloproliferative neoplasms

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Abstract Calreticulin (CALR) frameshift mutations drive the majority of JAK2/MPL-wild-type cases of essential thrombocythemia and myelofibrosis, producing a shared novel C-terminus that activates the thrombopoietin receptor and leads to constitutive Janus kinase (JAK)/signal…

I Need to Manage My Fatigue While Living With Cancer

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Key Takeaways Long-term survivorship can resemble a chronic condition, with enduring toxicities and continuous therapy requirements rather than discrete treatment and recovery. Chemotherapy-related hearing loss and severe dental complications can be psychologically traumatic and…

Insights to provider practice of germline testing for inherited hematologic malignancy predisposition syndromes to inform hematopoietic stem cell transplantation 

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Highlights -Considerable heterogeneity exists in germline testing implementation across hematopoietic stem cell transplantation centers in the United States. -Lack of standardized protocols affects the timing of testing and inconsistent sample collection workflows. -Barriers to…

Reduced Cumulative Post-Transplant Cyclophosphamide Exposure Is Associated with Increased Acute and Chronic Graft-versus-Host Disease After Allogeneic Hematopoietic Cell Transplantation

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Highlights Reduced cumulative post-transplant cyclophosphamide (<100 mg/kg) was associated with increased acute GVHD. Lower PTCy exposure independently increased moderate-to-severe chronic GVHD and second-line GVHD treatment. Reduced PTCy exposure did not significantly affect…

Post-transplant hypomethylating agents plus venetoclax maintenance improves survival in high-risk myeloid malignancies: A matched cohort study

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Relapse is the leading cause of allogeneic hematopoietic stem cell transplant (allo-HSCT) failure in myeloid neoplasms [1]. Patients receiving reduced-intensity conditioning (RIC) regimens have a higher risk of post-transplant relapse compared to those undergoing myeloablative…

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