Bone marrow failure Bone marrow failure: A condition that occurs when the bone marrow stops making enough healthy blood cells. The most common of these rare diseases are aplastic anemia, myelodysplastic syndromes (MDS) and paroxysmal nocturnal hemoglobinuria (PNH). Bone marrow failure can be acquired (begin any time in life) or can be… includes other diseases and conditions that are related to aplastic anemia aplastic anemia: (ay-PLASS-tik uh-NEE_mee-uh) A rare and serious condition in which the bone marrow fails to make enough blood cells - red blood cells, white blood cells, and platelets. The term aplastic is a Greek word meaning not to form. Anemia is a condition that happens when red blood cell count is low. Most… , MDS and PNH. AAMDSIF extends its programs, services and support to patients and families suffering from these rare diseases as well.
Chronic Lymphocytic Leukemia (CLL)
Chronic lymphocytic leukemia is a type of blood, lymph node and bone marrow bone marrow: The soft, spongy tissue inside most bones. Blood cells are formed in the bone marrow. cancer in which too many abnormal white blood cells called lymphocytes accumulate in your body.
Chronic Myelomonocytic Leukemia (CMML)
Chronic myelomonocytic leukemia is a type of blood and bone marrow cancer in which the bone marrow makes too many abnormal blood cells, including monocytes (a type of white blood cell white blood cell: Cells in the body that fight disease and infection by attacking and killing germs. There are several types of white blood cells including neutrophils, eosinophils, basophils, lymphocytes and monocytes. Each type of cell fights a different kind of germ. Also called WBC, leukocyte. ). The monocytes may also have an abnormal shape or size (dysplastic).
Graft vs. Host Disease (GVHD)
Graft versus host disease (GVHD) is a common complication of a stem cell/bone marrow transplant. It happens when the donor's immune cells, now in the patient, begin to see the patient's body as foreign, triggering an immune response to attack.
Myelofibrosis (MF)
Myelofibrosis is a bone marrow disorder where the marrow is replaced with fibrous scar tissue. It can lead to low blood cell counts and an enlarged spleen. It is considered a myeloproliferative neoplasm (MPN).
Chronic Myeloproliferative Neoplasms (MPN)
Chronic myeloproliferative neoplasms are a group of diseases in which the bone marrow makes too many red cells, white cells or platelets. There are six different type of MPNs.
Pure Red Cell Aplasia (PRCA)
Pure red cell aplasia (PRCA) is a condition in which the bone marrow stops making red blood cells, causing anemia anemia: (uh-NEE-mee-uh) A condition in which there is a shortage of red blood cells in the bloodstream. This causes a low red blood cell count. Symptoms of anemia are fatigue and tiredness. as well as reticulocytopenia, which is the absence of young red cells.