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Cell-autonomous dysregulation of interferon signaling drives clonal expansion of SRSF2-mutant MDS stem/progenitor cells

Key Points
SRSF2 mutations blunt responsiveness of MDS cells to IFN stimulation and promote their clonal fitness by downregulating STAT1 expression

Proteasome inhibition restores STAT1 protein level and sensitivity of SRSF2-mutant MDS cells to IFN, suggesting a new therapeutic strategy

Initial management of patients with acquired aplastic anemia in the United States: results from a large national claims database

Author(s): 
Stempel JM, Wang R, Lee AI, Zeidan AM, Ma X, Podoltsev NA
Primary Author: 
Stempel JM
Journal Title: 
Annals of Hematology
Original Publication Date: 
Apr 2025

Acquired

Bone Marrow Disease(s): 

Elderly Patients With Aplastic Anemia: Treatment Patterns and Outcomes in the Real World

Author(s): 
Fattizzo B, Gurnari C, Giammarco S, Ricchiuti A, Awada H, Bortolotti M, Galli N, Pedone GL, Versino F, Consonni D, Trikha R, Gandhi S, Sica S, Maciejewski JP, Kulasekararaj A, Barcellini W
Primary Author: 
Fattizzo B
Journal Title: 
American Journal of Hematology
Original Publication Date: 
Apr 2025

We retrospectively analyzed a large international cohort of 1113 patients with

Bone Marrow Disease(s): 

2025 Boston Patient and Family Conference

CONFERENCE AGENDA - September 27, 2025
(Eastern Time Zone)

Register Now for the 2025 Boston Patient and Family Conference
Event Date: 
Sat, 09/27/2025 - 7:30am (EDT)
Conference Event Type: 

2025 Chapel Hill Patient and Family Conference

CONFERENCE AGENDA - October 18, 2025
(Eastern Time Zone)

Register Now for the 2025 Chapel Hill Patient and Family Conference
Event Date: 
Sat, 10/18/2025 - 7:30am (EDT)
Conference Event Type: 

March for Marrow: Walk for PNH NJ / NY

Join us in Verona Park, NJ on Sunday, September 28, 2025 for a day of remembrance and awareness in celebration of the 19th Annual Walk for PNH.

The Walk for PNH is the nation's largest event to raise awareness and funds for PNH education and research. This inspiring event calls on participants of all ages and abilities to join in the fight against PNH.

Event Date: 
Sun, 09/28/2025 - 10:30am (EDT)
Community Event Type: 

Hack for Marrow

Hack for Marrow is a week-long global hackathon designed for teenagers aged 13 to 19. Whether you're a passionate coder or exploring programming for the first time, we’d love to have you join us!

Participants may compete individually or in teams of up to three members. To register, simply click the “Register” button above to sign up as an individual or with your team.

Event Date: 
Fri, 08/01/2025 - 12:00am (EDT) to Fri, 08/08/2025 - 11:59pm (EDT)
Bone Marrow Disease(s): 
Community Event Type: 

Terminal complement inhibition and control of hemolysis in patients with paroxysmal nocturnal hemoglobinuria who switched from high-dose eculizumab to ravulizumab: a phase IV, single-arm clinical trial

Author(s): 
Griffin M, Gandhi S, Kelly RJ, Munir T, Trikha R, Hicks E, Jain D, Ogawa M, Yu J, Muus P, Kulasekararaj AG
Primary Author: 
Griffin M
Journal Title: 
Haematologica
Original Publication Date: 
Apr 2025
Bone Marrow Disease(s): 

EPYSQLI (SB12; Biosimilar to Reference Eculizumab) in Asian and Non-Asian Patients With Paroxysmal Nocturnal Hemoglobinuria: Subgroup Analysis of a Global Phase III Randomized Controlled Trial

Author(s): 
Jang JH, Tomuleasa C, Oliynyk H, Lanamtieng T, Park J, Kim Y, Jung J, Russo P, Lim SM, Peffaultde Latour R
Primary Author: 
Jang JH
Journal Title: 
eJHaem
Original Publication Date: 
Mar 2025

Introduction: SB12 demonstrated equivalence to reference eculizumab (ECU) in complement inhibitor-naïve patients with

Bone Marrow Disease(s):