2026 Columbus Patient and Family Conference
Saturday, October 24, 2026
Conference Co-Chairs
Uma Borate, MBBS
Alice Mims, MD
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Myelodysplastic Syndromes (MDS) Donate to Support Our Mission
Saturday, October 24, 2026
Conference Co-Chairs
Uma Borate, MBBS
Alice Mims, MD
Dr. Chen is currently with the Rutgers Cancer Institute, the only NCI-designated cancer center in the state, where cutting-edge cancer research is conducted and state-of-the-art cancer care is delivered. Her interest in hematological malignancies started in medical school, driving her to pursue research in this field. After graduating from West China Medical School, she joined the University of Cincinnati’s Cancer and Cell Biology program, where her primary research focused on targeting autophagy in acute leukemia and earned my PhD. Following this, she completed her internal medicine residency
Myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML) are clonal myeloid neoplasms shaped by genetic lesions and immune dysregulation, both of which contribute to disease progression and poor outcomes. Existing prognostic systems, such as IPSS-R and IPSS-M, do not incorporate immune alterations. We assessed the biological and clinical relevance of an immune dysfunction signature (IDS) across multi-center MDS and CMML cohorts. IDS scores, derived from bulk transcriptomic data, were significantly associated with inferior leukemia-free and overall survival.