Myelodysplastic Syndromes (MDS)
An Immune Dysfunction Signature Score Predicts Survival in MDS Patients: Insights From a Longitudinal, Multicenter Study
Myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML) are clonal myeloid neoplasms shaped by genetic lesions and immune dysregulation, both of which contribute to disease progression and poor outcomes. Existing prognostic systems, such as IPSS-R and IPSS-M, do not incorporate immune alterations. We assessed the biological and clinical relevance of an immune dysfunction signature (IDS) across multi-center MDS and CMML cohorts. IDS scores, derived from bulk transcriptomic data, were significantly associated with inferior leukemia-free and overall survival.
Fueling Your Journey: Nutrition Support for Aplastic Anemia, MDS, and PNH
Topic(s)
Aplastic Anemia
Living Well with Bone Marrow Failure
Managing Your Treatment
Myelodysplastic Syndromes (MDS)
Paroxysmal Nocturnal Hemoglobinuria (PNH)
In this webinar, Sondos Khattab, Registered Dietitian, will discuss practical tips for managing treatment-related challenges, food safety, and making informed nutrition choices to support overall health. Questions can be submitted in advance at help@aamds.org.
Inherited Disorders
Topic(s)
Aplastic Anemia
Myelodysplastic Syndromes (MDS)
Presenter(s)
Sioban Keel, MD
Dr. Sioban Keel discusses inherited disorders, genetic testing, how these disorders are diagnosed, and their impact on treatment decisions and care.
MDS Transplant
Topic(s)
Myelodysplastic Syndromes (MDS)
Presenter(s)
Naveed Ali, MD
Dr. Naveed Ali provides an overview of transplantation for myelodysplastic syndromes (MDS), when a transplant may be recommended, the transplant process, potential risks and benefits, recovery, and long-term follow-up.
Leukemic Transformation From the 2026 AAMDSIF Seattle Patient and Family Conference
Topic(s)
Acute Myeloid Leukemia (AML)
Myelodysplastic Syndromes (MDS)
Presenter(s)
Anna Halpern, MD
Dr. Anna Halpern discusses how leukemic transformation is identified, what it means for prognosis, and how patients and their healthcare teams can navigate treatment decisions.
MDS Non-Transplant Session from the 2026 AAMDSIF Seattle Patient and Family Conference
Topic(s)
Myelodysplastic Syndromes (MDS)
Presenter(s)
Anna Halpern, MD
Dr. Anna Halpern discusses the signs and symptoms of aplastic anemia, current diagnostic approaches, available treatment options, and the latest advances in patient care.
What is my diagnosis? From the 2026 AAMDSIF Patient and Family Conference
Topic(s)
Aplastic Anemia
Myelodysplastic Syndromes (MDS)
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Presenter(s)
Bart Scott, MD
Dr. Bart Scott provides an overview of aplastic anemia, myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), and paroxysmal nocturnal hemoglobinuria (PNH). He explains the diagnostic tests and criteria used to make an accurate diagnosis.