Grants and Grant Recipients
Grant Year: 2011
Dr. Dao will investigate why the blood
stem cells
stem cells:
Cells in the body that develop into other cells. There are two main sources of stem cells. Embryonic stem cells come from human embryos and are used in medical research. Adult stem cells in the body repair and maintain the organ or tissue in which they are found. Blood-forming (hemapoietic) stem…
from patients who inherit a loss-of-function
mutation
mutation:
Any change or alteration in a gene. A mutation may cause disease or may be a normal variation. Paroxysmal nocturnal hemoglobinuria (PNH) occurs because…
Dr. McCrae's study explores why patients with PNH are at increased risk for the development of
thrombosis
thrombosis:
(throm-BOE-suss) A blood clot (thrombus) that develops and attaches to a blood vessel.
, or blood clots, that may affect arteries or veins and cause events such as pulmonary emboli or stroke.
Dr. Mehta will study the use of Quercetin, a naturally occurring flavonoid (antioxidant) in patients with
Fanconi anemia
Fanconi anemia:
A rare inherited disorder that happens when the bone marrow does not make enough blood cells (red cells, white cells, and platelets). Fanconi anemia is diagnosed early in life. People with Fanconi anemia have a high likelihood of developing cancer. Genetic testing is used to diagnose Fanconi anemia.
, one of the most common congenital
bone marrow failure
bone marrow failure:
A condition that occurs when the bone marrow stops making…
TET2 is one of the most frequently mutated genes identified in patients with
myelodysplastic syndromes
myelodysplastic syndromes:
(my-eh-lo-diss-PLASS-tik SIN-dromez) A group of disorders where the bone marrow does not work well, and the bone marrow cells fail to make enough healthy blood cells. Myelo refers to the bone marrow. Dysplastic means abnormal growth or development. People with MDS have low blood cell count for at…
(MDS). This study will help explore new avenues for the cure TET2 mutations, and Dr. Mukherji says he and his colleagues “will use our expertise to…
