paroxysmal nocturnal hemoglobinuria (PNH) | Page 21 | Aplastic Anemia & MDS International Foundation

paroxysmal nocturnal hemoglobinuria (PNH)

Selectivity of C3-opsonin targeted complement inhibitors: A distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients

Author(s): 
Schmidt CQ, Harder MJ, Nichols EM, Hebecker M, Anliker M, Höchsmann B, Simmet T, Csincsi ÁI, Uzonyi B, Pappworth IY, Ricklin D, Lambris JD, Schrezenmeier H, Józsi M, Marchbank KJ
Primary Author: 
Schmidt CQ
Journal Title: 
Immunobiology
Original Publication Date: 
Jan 2016

Impact of eculizumab treatment on paroxysmal nocturnal hemoglobinuria: A treatment versus no-treatment study

Author(s): 
Loschi M, Porcher R, Barraco F, Terriou L, Mohty M, de Guibert S, Mahe B, Lemal R, Dumas PY, Etienne G, Jardin F, Royer B, Bordessoule D, Simon Rohrlich P, Fornecker LM, Salanoubat C, Maury S, Cahn JY, Vincent L, Sene T, Rigaudeau S, Nguyen S, Lepretre AC
Primary Author: 
Loschi M
Journal Title: 
Am J Hematol
Original Publication Date: 
Dec 2015

Intravascular hemolysis in

Assessment of Human Antihuman Antibodies to Eculizumab After Long-Term Treatment in Patients With Paroxysmal Nocturnal Hemoglobinuria

Author(s): 
Hillmen P, Muus P, Szer J, Hill A, Höchsmann B, Kulasekararaj A, Risitano AM, Van Den Neste E, Liljeholm M, Ebrahim KS, Bedrosian CL, Gao X, Ames D, Socié G
Primary Author: 
Hillmen P
Journal Title: 
Am J Hematol
Original Publication Date: 
Dec 2015

No abstract available.

PNH - Paroxysmal Nocturnal Hemoglobinuria

PNH, or Paroxysmal nocturnal hemoglobinuria is an ultra-rare bone marrow failure disease in which red blood cells break apart. Normal red blood cells have a shield of proteins that protect them from coming under attack by the body's own immune system. PNH occurs because that protein shield is missing. PNH is often associated with reduced bone marrow function (low blood counts) caused by aplastic anemia.