News and Treatment Updates

Here's where you'll find a regularly updated, broad range of articles written by the AAMDSIF team, allied health organizations and news organizations. By staying well-informed, patients and families are practicing a form of self-support that will help them be more effective self-advocates when engaging with health care providers.

Stag2-dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome

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Key Points Stag2 reprograms Gata1 cistrome specificity via chromatin accessibility, a key determinant of transcription factor lineage discrimination. Loss of the Stag2 rheostat causes accessibility-driven Gata1 retargeting, providing a mechanistic framework for dyserythropoiesis…

Clinical heterogeneity and outcome of acquired PRCA: a multicenter European study

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Key Points PRCA shows marked diagnostic heterogeneity, where molecular data can help identify challenging secondary forms, such as MDS-associated cases. Early initiation of CyA improves outcomes; mTORi are valuable second-line treatment. Infection related mortality remains non…

AAML1831: A Phase III Trial Comparing Standard Induction Therapy With CPX-351 in De Novo Pediatric AML: A Report From the Children's Oncology Group

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Abstract Purpose The Children's Oncology Group phase III clinical trial AAML1831 (ClinicalTrials.gov identifier: NCT04293562) evaluated liposomal daunorubicin and cytarabine (CPX-351) versus standard daunorubicin/cytarabine (DA) induction therapy in children and young adults with…

Patient and Caregiver Involvement With Prior Authorization and Care Delivery and Delays

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Introduction Payers employ health care utilization–management strategies, including prior authorization (PA), to limit costs and promote evidence-based, guideline-concordant care. However, PA may be inconsistently applied and associated with patient confusion and frustration.1-3…

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