News and Treatment Updates

Here's where you'll find a regularly updated, broad range of articles written by the AAMDSIF team, allied health organizations and news organizations. By staying well-informed, patients and families are practicing a form of self-support that will help them be more effective self-advocates when engaging with health care providers.

Comparison of Late Effects and Quality of Life by Donor Type in Long-Term Survivors of Severe Aplastic Anemia after Hematopoietic Cell Transplantation

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Highlights The analysis included 122 survivors who underwent HCT between 1972 and 2021 with a median interval between HCT and survey of 26.0 (range 1.1 to 47.1) yr. The most common reported chronic health conditions were problems with sexual desire, erection, ejaculation, vaginal…

Immunotherapeutic targeting of calreticulin mutant myeloproliferative neoplasms

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Abstract Calreticulin (CALR) frameshift mutations drive the majority of JAK2/MPL-wild-type cases of essential thrombocythemia and myelofibrosis, producing a shared novel C-terminus that activates the thrombopoietin receptor and leads to constitutive Janus kinase (JAK)/signal…

Outcomes After Matched Sibling Donor Versus Haploidentical Hematopoietic Stem Cell Transplantation With Post-Transplant Cyclophosphamide-Based GVHD Prophylaxis 

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Highlights Haploidentical HSCT with post-transplant cyclophosphamide yields overall and disease-free survival rates statistically comparable to matched sibling donor transplants. Multivariable analysis confirms that GVHD-free/relapse-free survival (GRFS) outcomes are equivalent…

I Need to Manage My Fatigue While Living With Cancer

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Key Takeaways Long-term survivorship can resemble a chronic condition, with enduring toxicities and continuous therapy requirements rather than discrete treatment and recovery. Chemotherapy-related hearing loss and severe dental complications can be psychologically traumatic and…

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