News and Treatment Updates

Here's where you'll find a regularly updated, broad range of articles written by the AAMDSIF team, allied health organizations and news organizations. By staying well-informed, patients and families are practicing a form of self-support that will help them be more effective self-advocates when engaging with health care providers.

Insights to provider practice of germline testing for inherited hematologic malignancy predisposition syndromes to inform hematopoietic stem cell transplantation 

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Highlights -Considerable heterogeneity exists in germline testing implementation across hematopoietic stem cell transplantation centers in the United States. -Lack of standardized protocols affects the timing of testing and inconsistent sample collection workflows. -Barriers to…

Reduced Cumulative Post-Transplant Cyclophosphamide Exposure Is Associated with Increased Acute and Chronic Graft-versus-Host Disease After Allogeneic Hematopoietic Cell Transplantation

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Highlights Reduced cumulative post-transplant cyclophosphamide (<100 mg/kg) was associated with increased acute GVHD. Lower PTCy exposure independently increased moderate-to-severe chronic GVHD and second-line GVHD treatment. Reduced PTCy exposure did not significantly affect…

Post-transplant hypomethylating agents plus venetoclax maintenance improves survival in high-risk myeloid malignancies: A matched cohort study

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Relapse is the leading cause of allogeneic hematopoietic stem cell transplant (allo-HSCT) failure in myeloid neoplasms [1]. Patients receiving reduced-intensity conditioning (RIC) regimens have a higher risk of post-transplant relapse compared to those undergoing myeloablative…

Stag2-dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome

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Key Points Stag2 reprograms Gata1 cistrome specificity via chromatin accessibility, a key determinant of transcription factor lineage discrimination. Loss of the Stag2 rheostat causes accessibility-driven Gata1 retargeting, providing a mechanistic framework for dyserythropoiesis…

Long-Term Gynecologic and Reproductive Health in Female Survivors of Allogeneic Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-analysis of Prevalence 

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Allogeneic hematopoietic stem cell transplantation (allo-HCT) remains a potentially curative therapy for various hematologic malignancies, bone marrow failure syndromes, and selected nonmalignant disorders. Advances in conditioning regimens, graft-versus-host disease (GVHD)…

Clinical heterogeneity and outcome of acquired PRCA: a multicenter European study

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Key Points PRCA shows marked diagnostic heterogeneity, where molecular data can help identify challenging secondary forms, such as MDS-associated cases. Early initiation of CyA improves outcomes; mTORi are valuable second-line treatment. Infection related mortality remains non…

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