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treatment

APR-246

A methylated derivative and structural analog of PRIMA-1 (p53 re-activation and induction of massive apoptosis), with potential antineoplastic activity. Upon administration, PRIMA-1 analog APR-246 covalently modifies the core domain of mutated forms of cellular tumor antigen p53 (p53) through the alkylation of thiol groups.

Rodrigo Calado, MD, PhD

Calado, Rodrigo
Associate Professor
Hospital das Clínicas de Ribeirão Preto

Graduated in Medicine (1997) and PhD in Clinical Medicine (2003) from the Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP) and medical residency in Hematology and Hemotherapy (2001) from the Hospital das Clinicas of FMRP-USP. He did postdoctoral studies at the National Institutes of Health, Bethesda, Maryland, USA, where he also worked as a Staff Scientist at the Hematology Branch until 2011.

Ashley and Alayna: A Mother's Story

Person's Name: 
Ashley Numbers

September 16 through December 20 will stand out in Ashley’s mind.

Forever.

These are the days she spent in the hospital with her feisty three-year-old, Alayna, for conditioning and bone marrow transplant.

The summer of 2019 was already big with a wedding to plan.  The toddler and her baby brother were enjoying everything that small ones do, including riding dirt bikes with Daddy.

Bone Marrow Disease(s): 
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