Paroxysmal Nocturnal Hemoglobinuria (PNH)

The rapid spread of the coronavirus disease 2019 (COVID-19) pandemic has challenged healthcare systems to re-organize the management of patients in a short period. The causative pathogen of this pandemic is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), one of seven coronaviruses that can be found in humans. It is a rapidly mutating, enveloped, ssRNA, beta-coronavirus. The initial reports published after the pandemic spread showed a transmissibility rate of 2.2 and possibly low values of dispersion.

Ravulizumab every 8 weeks showed non-inferiority to eculizumab eculizumab: Eculizumab (Soliris ®) is given as an IV into a vein at the doctor’s office or at a special center.

While red blood cells (RBCs) and granulocytes have been more studied, platelets and reticulocytes are not commonly used in paroxysmal nocturnal hemoglobinuria

The complement system complement system: A group of proteins that move freely in the bloodstream.

Patients with paroxysmal nocturnal hemoglobinuria paroxysmal nocturnal hemoglobinuria:

The current standard of care for paroxysmal nocturnal hemoglobinuria paroxysmal nocturnal hemoglob