Hypomethylating agents (HMAs) are the current standard of care in high-risk myelodysplastic syndromes myelodysplastic syndromes:
Chronic inflammation has been implicated in myelodysplastic syndrome (MDS); however, its role in disease progression is unclear.
An immunosuppressive microenvironment promoting leukemia cell immune escape plays an important role in the pathogenesis of AML. Through its interaction with cereblon, a substrate receptor for the E3 ubiquitin ligase complex, pomalidomide leads to selective ubiquitination of transcription factors Aiolos and Ikaros thereby promoting immune modulation.
Myelodysplastic syndrome/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T) is a disease entity characterized by anemia anemia: (uh-NEE-mee-uh) A condition in which there is a shortage of
In the current World Health Organization (WHO)-classification, therapy-related myelodysplastic syndromes myelodysplastic syndromes:
Our understanding of the genetics of acute myeloid leukemia acute myeloid leukemia: (uh-KYOOT my-uh-LOYD loo-KEE-mee-uh) A cancer of the bloo
Acquired aplastic anemia aplastic anemia: (ay-PLASS-tik uh-NEE_mee-uh) A rare and serious condition in which the bone marrow fails to make enough blood cells - red blood cells,