aplastic anemia | Page 39 | Aplastic Anemia & MDS International Foundation

aplastic anemia

Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia.

Author(s): 
Calado RT, Cooper JN, Padilla-Nash HM, Sloand EM, Wu CO, Scheinberg P, Ried T, Young NS
Primary Author: 
Calado RT
Journal Title: 
Leukemia
Original Publication Date: 
Oct 2011

In cell and animal models,

Bone Marrow Diseases: 

Frequent loss of HLA alleles associated with copy number-neutral 6pLOH in acquired aplastic anemia.

Author(s): 
Katagiri T, Sato-Otsubo A, Kashiwase K, Morishima S, Sato Y, Mori Y, Kato M, Sanada M, Morishima Y, Hosokawa K, Sasaki Y, Ohtake S, Ogawa S, Nakao S.
Primary Author: 
Katagiri T
Journal Title: 
Blood
Original Publication Date: 
Sep 2011
Bone Marrow Diseases: 

Nutritional support in the treatment of aplastic anemia

Author(s): 
Jia L, Yu J, He L, Wang H, Jiang L, Miao X, Wu W, Yang P
Primary Author: 
Jia L
Journal Title: 
Nutrition
Original Publication Date: 
May 2011

OBJECTIVE:

Whether a specific nutritional support promotes healing of aplastic anemia (AA) patients is still unclear. Therefore, we explored the potential of a high-nucleotide, arginine, and micronutrient nutritional supplement on the nutritional rehabilitation of AA mice.
METHODS:

The BALB/c AA mice model was treated with hypodermic injections of acetylphenylhydrazine (100 mg/kg), x-ray (2.0 Gy), and intraperitoneal injections of a cyclophosphamide (80 mg/kg) combination. Then AA mice were fed with nutritional supplements in a dose-dependent manner (1445.55, 963.7, 674.59 mg/kg/d) for 7 wk. At the end of the experimental period, mice were autopsied. A full blood count was performed, and femoral marrow cell suspensions were prepared to assess the total femoral nucleated cell count and the number of committed hemopoietic progenitor cells (colony-forming units). The pathologic changes of liver and spleen were analyzed.

RESULTS:

Bone Marrow Diseases: 

Effect of stem cell source on outcomes after unrelated donor transplantation in severe aplastic anemia

Author(s): 
Eapen M, Le Rademacher J, Antin JH, Champlin RE, Carreras J, Fay J, Passweg JR, Tolar J, Horowitz MM, Marsh JC, Deeg HJ
Primary Author: 
Eapen M
Journal Title: 
Blood
Original Publication Date: 
Jun 2011

Outcome after unrelated donor

Bone Marrow Diseases: 

Acceptable HLA-mismatching in unrelated donor bone marrow transplantation for patients with acquired severe aplastic anemia

Author(s): 
Yagasaki H, Kojima S, Yabe H, Kato K, Kigasawa H, Sakamaki H, Tsuchida M, Kato S, Kawase T, Morishima Y, Kodera Y
Primary Author: 
Yagasaki H
Journal Title: 
Blood
Original Publication Date: 
Jul 2011

We retrospectively analyzed the impact of HLA mismatching (HLA-A, -B, -C, -DRB1, -DQB1) using molecular typing on transplant outcome for 301 patients with acquired severe

Bone Marrow Diseases: 

Efficacy of rabbit anti-thymocyte globulin in severe aplastic anemia

Author(s): 
Afable MG 2nd, Shaik M, Sugimoto Y, Elson P, Clemente M, Makishima H, Sekeres MA, Lichtin A, Advani A, Kalaycio M, Tiu RV, O'Keefe CL, Maciejewski JP
Primary Author: 
Afable MG 2nd
Journal Title: 
Haematologica
Original Publication Date: 
May 2011

Background A combination of horse anti-thymocyte globulin and

Bone Marrow Diseases: