Newsstand | Aplastic Anemia & MDS International Foundation

Newsstand

Here's where you'll find a regularly updated, broad range of articles written by the AAMDSIF team, allied health organizations and news organizations. By staying well-informed, patients and families are practicing a form of self-support that will help them be more effective self-advocates when engaging with health care providers.

APLASTIC ANEMIA and MDS INTERNATIONAL FOUNDATION ANNOUNCES NEW EXECUTIVE DIRECTOR - Nonprofit Executive Janice Frey-Angel Assumes Role December 1, 2020

Originally Published: 11/24/2020
FOR IMMEDIATE RELEASE November 24, 2020 APLASTIC ANEMIA and MDS INTERNATIONAL FOUNDATION ANNOUNCES NEW EXECUTIVE DIRECTOR Nonprofit Executive Janice Frey-Angel Assumes Role December 1, 2020 November 24, 2020; BETHESDA, MARYLAND –  The Aplastic Anemia and MDS International Foundation (AAMDSIF), the world's leading nonprofit health organization dedicated to supporting patients and families living with bone marrow failure diseases, announced today that Janice Frey-Angel has been named the Foundation's new Chief Executive Officer and Executive Director. Ms. Frey-Angel succeeds Neil Horikoshi,...

Seventh International Bone Marrow Failure Scientific Symposium - Summary for Patients

Originally Published: 11/18/2020
We are pleased to present this Summary for Patients of the Seventh AAMDSIF International Bone Marrow Failure Scientific Symposium held virtually on July 15, 16 & 17, 2020. Our Symposium brought together many of the worldʼs leading experts on the biology and treatment of aplastic anemia, myelodysplastic syndromes, paroxysmal nocturnal hemoglobinuria, acute myeloid leukemia and related disorders. Despite the virtual format due to the coronavirus pandemic, our registration was higher than ever, with over 750 participants from 38 nations. The Aplastic Anemia and MDS International Foundation...

Human and artificial intelligence to illuminate MDS

Originally Published: 11/12/2020
In this issue of Blood, Nagata et al show for the first time that machine learning (ML) algorithms can discern patterns and identify diagnostically and prognostically relevant associations between genetic variants and cytomorphological changes in myelodysplastic syndromes (MDS), correlations that are too subtle or complex for the human eye to observe. We know about many phenotype-genotype correlations in hematology, including PML-RARA and the classic hypergranular abnormal promyelocytes of acute promyelocytic leukemia, germline GATA2 mutations, and myelokathexis. In MDS, examples include the...

New Strategies Improve Outcomes for Lower-Risk MDS

Originally Published: 11/04/2020
Myelodysplastic syndrome (MDS) is a challenging and complicated disease with median outcomes ranging from 5.3 years in patients with lower-risk disease to just 8.4 months in the very high-risk population.1,2 However, newly approved agents entering the armamentarium are providing better outcomes for patients with MDS, especially for those with lower-risk disease. Gail J. Roboz, MD, professor of medicine and director of the Clinical and Translational Leukemia Program at the Weill Medical College of Cornell University and the NewYork-Presbyterian Hospital, detailed potential causes and risk...

Beat AML Master Clinical Trial Showcases Paradigm Shift With Precision Medicine

Originally Published: 10/28/2020
Delaying treatment for up to 7 days so that genomic data can be utilized to inform a personalized treatment approach is safe, feasible, and can improve overall survival in patients with acute myeloid leukemia. John C. Byrd, MD Delaying treatment for up to 7 days so that genomic data can be utilized to inform a personalized treatment approach is safe, feasible, and can improve overall survival (OS) in patients with acute myeloid leukemia (AML), according to results from the Beat AML Master clinical trial (NCT03013998) published in Nature Medicine.1 Results showed that the trial met its...

Outcomes of patients with hematologic malignancies and COVID-19: A systematic review and meta-analysis of 3377 patients

Originally Published: 10/28/2020
Key Points Adult patients with hematologic malignancy and COVID-19 have a 34% risk of death, while pediatric patients have a 4% risk of death. Patients on systemic anti-cancer therapy had a similar risk of death to patients on no treatment (RR 1.17, 95% CI 0.83-1.64). Outcomes for patients with hematologic malignancy infected with COVID-19 have not been aggregated. The objective of this study was to perform a systematic review and meta-analysis to estimate the risk of death and other important outcomes for these patients. We searched Pubmed and EMBASE up to August 20, 2020, to identify...

Does Cancer Chemotherapy Increase My Covid Risks?

Originally Published: 10/07/2020
By Mikkael A. Sekeres, M.D. Oct. 7, 2020 Q. I have cancer and am being treated with chemotherapy. Am I at increased risk of getting sick and dying from Covid-19? A. People with cancer, and particularly those with leukemia, seem to have a higher death rate from Covid-19 than the general population, though cancer chemotherapy does not appear to further increase the risk of dying from Covid. Studies, however, have been limited and results are sometimes difficult to interpret. Many types of chemotherapy work by disrupting the cancer cell’s machinery that allows it to divide and grow so rapidly...

Rogue Antibodies and Gene Mutations Explain Some Cases of Severe COVID-19

Originally Published: 10/06/2020
One of the many perplexing issues with COVID-19 is that it affects people so differently. That has researchers trying to explain why some folks bounce right back from the virus, or don’t even know they have it—while others become critically ill. Now, two NIH-funded studies suggest that one reason some otherwise healthy people become gravely ill may be previously unknown trouble spots in their immune systems, which hamper their ability to fight the virus. According to the new findings in hundreds of racially diverse people with life-threatening COVID-19, a small percentage of people who...

Foundation Update Newsletter September 2020

Originally Published: 09/22/2020