Low Dose Danazol for the Treatment of Telomere Related Diseases | Aplastic Anemia & MDS International Foundation Return to top.

ClinicalTrials.gov Identifier:

NCT03312400

Contact Info

Ivana Darden
Ivana.darden@nih.gov
301-827-2988

Dates

Start: March 2018
End: April 2026

Official Title

Low Dose Danazol for the Treatment of Telomere Related Diseases

Purpose

DNA is a structure in the body. It contains data about how the body develops and works. Telomeres are found on the end of chromosomes in DNA. Some people with short telomeres or other gene changes can develop diseases of the bone marrow, lung, and liver. Researchers at the National Institutes of Health (NIH) are studying if the medication danazol can be used to treat people with short telomere disease who also have bone marrow failure, liver, or lung disease.In recent studies, danazol, at high doses, showed a positive influence on telomere length. Additional research is needed to learn more about the role of different doses of danazol on telomere disease as well as its effects on secondary diseases.

Low Dose Danazol for the Treatment of Telomere Related Diseases

Clinical Trial: NCT03312400

Instructions

If you are interested in learning more about your possible participation in this clinical trial, please complete the form. Your information will be forwarded directly to the sponsoring company.

Status: 
Recruiting
Phase: 
Phase 2
Gender: 
Female
Male
Age Group: 
3 years and older
Accepts Healthy Volunteers: 
No
Inclusion Criteria: 

Eligible participants:

  • Are 3 and older (minors must have parent/guardian consent to participate);
  • Are diagnosed with a short telomere disease;
  • Also have abnormalities affecting the bone marrow such as aplastic anemia or low blood counts OR lung disease OR liver disease.
Exclusion Criteria: 

Personal history of bone marrow transplant.

Find Out More:

Disclaimer:

AAMDSIF does not recommend, endorse, or make any representation about the efficacy, appropriateness or suitability of any clinical trial listed on this website. Pharmaceutical company sponsored content is highlighted only to give additional information about the trial. All trials are listed on https://clinicaltrials.gov/. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a clinical trial, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.

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