May 25, 2021

Clinical psychologist Jessica Pieczynski, PhD, offers insights into how practicing mindfulness techniques can help cancer survivors manage stress during the pandemic, and beyond.

It’s possible that 2020 will go down in history as the year of Murphy’s Law. The whole “what can go wrong, will go wrong” adage seems fitting for many as they navigate the economic, social and familial impact of the pandemic and cultural movements. Increased stress during these challenging times is the norm for even the healthiest among us.

Patients with

CC-486—the oral formulation of azacitidine—significantly improved RBC transfusion independence (RBC-TI) rates and induced durable bilineage improvements in patients with lower-risk

Key Points
Mesothelin is aberrantly expressed in over one third of childhood and young adult AML and not expressed on normal hematopoietic cells.

Mesothelin is successfully targeted in vitro and in xenograft models of MSLN+ AML with ADCs.

Abstract

With the goal of capitalizing on the efficacy observed with cellular therapies in acute leukemias, ongoing research efforts are underway to address unanswered questions regarding the role of transplant in conjunction with cellular therapy, optimal toxicity management, antigen escape, and methods to overcome myelosuppression and immunosuppression in these diseases, said Michael Grunwald, MD.

Highlights

• We analyzed naturally-occurring inpatient palliative care conversations.
• Existential communication is pervasive and varied in palliative care conversations
• Patients, families, and clinicians talk about time, the self, and connectedness.
• Findings help develop a lexicon for everyday existential communication.

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Key Points
Donor-derived T cells with native specificity for multiple myeloid leukemia antigens can be expanded ex vivo.

Infusion of mLSTs after HCT is well tolerated and produces antileukemia effects.

The SARS-CoV-2 pandemic has changed the world over the last year and impacted almost every part of our lives. In particular, patients with hematologic malignancies have been significantly affected by this crisis at every stage of their treatment. Delays in diagnosis and increased waiting times for transplants and therapy have become common occurrences. Patients with hematologic malignancies are also more likely to suffer from severe COVID-19, leading to a greater mortality rate.