paroxysmal nocturnal hemoglobinuria (PNH) | Page 35 | Aplastic Anemia & MDS International Foundation

paroxysmal nocturnal hemoglobinuria (PNH)

Paroxysmal nocturnal hemoglobinuria in pediatric patients.

Author(s): 
Curran KJ, Kernan NA, Prockop SE, Scaradavou A, Small TN, Kobos R, Castro-Malaspina H, Araten D, Dimichele D, O'Reilly RJ, Boulad F
Primary Author: 
Curran KJ
Journal Title: 
Pediatr Blood Cancer
Original Publication Date: 
Dec 2011

BACKGROUND:

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disease in children. The most significant clinical features of PNH include: bone marrow failure, intravascular hemolysis, and thrombosis. To further characterize the clinical presentation and outcome to treatment we performed a retrospective analysis of pediatric patients with PNH.

PROCEDURE:

We reviewed the medical records of 12 consecutive pediatric patients with PNH diagnosed at our institution from 1992 to 2010.

RESULTS:

Paroxysmal nocturnal hemoglobinuria and pregnancy before the eculizumab era: the French experience

Author(s): 
de Guibert S, Peffault de Latour R, Varoqueaux N, Labussière H, Rio B, Jaulmes D, Eveillard JR, Dulucq S, Stoppa AM, Bouscary D, Girodon F, Bonnotte B, Laskri D, Socié G, Lamy T.
Primary Author: 
de Guibert S
Journal Title: 
Haematologica
Original Publication Date: 
May 2011

Background Pregnancy in women with

Chronic treatment of paroxysmal nocturnal hemoglobinuria patients with eculizumab: safety, efficacy, and unexpected laboratory phenomena

Author(s): 
Röth A, Hock C, Konik A, Christoph S, Dührsen U
Primary Author: 
Röth A
Journal Title: 
Int J Hematol.
Original Publication Date: 
May 2011

The terminal complement inhibitor

Paroxysmal nocturnal hemoglobinuria following alemtuzumab immunosuppressive therapy for myelodysplastic syndrome and complicated by recurrent life-threatening thrombosis despite anticoagulation: successful intervention with eculizumab and fondaparinux

Author(s): 
Cheng KL, Brody J, Warshall CE, Sloand EM, Allen SL
Primary Author: 
Cheng KL
Journal Title: 
Leuk Res.
Original Publication Date: 
Apr 2010

No abstract available.