aplastic anemia | Page 41 | Aplastic Anemia & MDS International Foundation

aplastic anemia

Retrospective survey on the prevalence and outcome of prior autoimmune diseases in patients with aplastic anemia reported to the registry of the European group for blood and marrow transplantation.

Author(s): 
Cesaro S, Marsh J, Tridello G, Rovò A, Maury S, Montante B, Masszi T, Van Lint MT, Afanasyev B, Iriondo Atienza A, Bierings M, Carbone C, Doubek M, Lanino E, Sarhan M, Risitano A, Steinerova K, Wahlin A, Pegoraro A, Passweg J.
Primary Author: 
Cesaro S
Journal Title: 
Acta Haematol
Original Publication Date: 
Jul 2010

BACKGROUND:

Bone Marrow Diseases: 

Th17 immune responses contribute to the pathophysiology of aplastic anemia.

Author(s): 
de Latour RP, Visconte V, Takaku T, Wu C, Erie AJ, Sarcon AK, Desierto MJ, Scheinberg P, Keyvanfar K, Nunez O, Chen J, Young NS
Primary Author: 
de Latour RP
Journal Title: 
Blood
Original Publication Date: 
Aug 2010

T helper type 17 (Th17) cells have been characterized based on production of interleukin-17 (IL-17) and association with autoimmune diseases. We studied the role of Th17

Bone Marrow Diseases: 

Successful bone marrow transplantation for children with aplastic anemia based on a best-available evidence strategy.

Author(s): 
Okamoto Y, Kodama Y, Nishikawa T, Yamaki Y, Mougi H, Masamoto I, Tanabe T, Shinkoda Y, Kawano Y.
Primary Author: 
Okamoto Y
Journal Title: 
Pediatr Transplant
Original Publication Date: 
Jan 2010

  A best-available evidence strategy, i.e., the best-available donors, conditioning regimens and GVHD prophylaxis were chosen at the time of BMT for AA, was analyzed retrospectively. The outcomes for 18 children with AA who underwent allogeneic BMT were analyzed. The median age was 11 yr (range 4-16), and nine were men. As conditioning regimens, seven had low-dose irradiation + CY, six had ATG +

Bone Marrow Diseases: 

Impact of age on outcomes after bone marrow transplantation for acquired aplastic anemia using HLA-matched sibling donors.

Author(s): 
Gupta V, Eapen M, Brazauskas R, Carreras J, Aljurf M, Gale RP, Hale GA, Ilhan O, Passweg JR, Ringdén O, Sabloff M, Schrezenmeier H, Socié G, Marsh JC.
Primary Author: 
Gupta V
Journal Title: 
Haematologica
Original Publication Date: 
Sep 2010

BACKGROUND:

Transplantation from an HLA-matched sibling is the treatment of choice for young

Bone Marrow Diseases: 

Association of telomere length of peripheral blood leukocytes with hematopoietic relapse, malignant transformation, and survival in severe aplastic anemia.

Author(s): 
Scheinberg P, Cooper JN, Sloand EM, Wu CO, Calado RT, Young NS.
Primary Author: 
Scheinberg P
Journal Title: 
JAMA
Original Publication Date: 
Sep 2010

CONTEXT:

Critically short telomeres produce apoptosis, cell senescence, and chromosomal

Bone Marrow Diseases: 

Optimization of therapy for severe aplastic anemia based on clinical, biologic, and treatment response parameters: conclusions of an international working group on severe aplastic anemia convened by the Blood and Marrow Transplant Clinical Trials Network.

Author(s): 
Pulsipher MA, Young NS, Tolar J, Risitano AM, Deeg HJ, Anderlini P, Calado R, Kojima S, Eapen M, Harris R, Scheinberg P, Savage S, Maciejewski JP, Tiu RV, DiFronzo N, Horowitz MM, Antin JH.
Primary Author: 
Pulsipher MA
Journal Title: 
Biol Blood Marrow Transplant
Original Publication Date: 
Oct 2010

Although recent advances in therapy offer the

Bone Marrow Diseases: 

Comparison of Outcomes after Transplantation of G-CSF-Stimulated Bone Marrow Grafts versus Bone Marrow or Peripheral Blood Grafts from HLA-Matched Sibling Donors for Patients with Severe Aplastic Anemia.

Author(s): 
Chu R, Brazauskas R, Kan F, Bashey A, Bredeson C, Camitta B, Chiang KY, Frangoul H, Gale RP, Gee A, George B, Goldman FD, Gross TG, Gupta V, Hale GA, Isola L, Ispizua AU, Lazarus H, Marsh J, Russell J, Sabloff M, Waller EK, Eapen M.
Primary Author: 
Chu R
Journal Title: 
Biol Blood Marrow Transplant
Original Publication Date: 
Oct 2010

We compared outcomes of patients with severe

Bone Marrow Diseases: