patient | Page 4 | Aplastic Anemia and MDS International Foundation (AAMDSIF) Return to top.

patient

A clinical guide to TP53 mutations in myeloid neoplasms

TP53 mutations are found in 10-15% of myeloid neoplasms and are one of its most important prognostic factors. Emerging data show that TP53 mutational allele status is a key determinant of clinical outcomes, with multi-hit TP53 mutant myeloid neoplasms having a very poor prognosis. Significant differences exist among the methods used in clinical and research settings to assess TP53 mutational status, leading to variability in reported patient characteristics, response to therapy, and survival.