Newsstand | Page 6 | Aplastic Anemia & MDS International Foundation


Here's where you'll find a regularly updated, broad range of articles written by the AAMDSIF team, allied health organizations and news organizations. By staying well-informed, patients and families are practicing a form of self-support that will help them be more effective self-advocates when engaging with health care providers.

The Falling, Wandering and Crashing Business of Cancer Treatment Side Effects

Originally Published: 12/26/2019
With neuropathy as a result of treatment comes a whole host of issues. The first one I can think of? Oops, there goes the wine! In more ways than one, actually, as wine is probably one of the last things you can enjoy while undergoing chemo. And not only can you not enjoy it, but when you try to lift that glass onto your kitchen counter, neuropathy will cause you to instead bash it against the edge. Hopefully this was not your special glass. If you try it again while in treatment, pick the cheap old glass you got at a yard sale. No big loss. The bashing goes on for a while but it does get...

Woyach Highlights Progress and Next Steps in CLL Paradigm

Originally Published: 12/26/2019
With therapeutic additions to the treatment paradigm of chronic lymphocytic leukemia (CLL), it is now a question of which regimen to give patients in the frontline setting, explained Jennifer A. Woyach, MD. “In the frontline setting, our new options for targeted therapy include ibrutinib (Imbruvica), acalabrutinib (Calquence), and venetoclax (Venclexta) plus obinutuzumab (Gazyva). We have 3 great targeted therapy options. One of the difficulties right now is that we have such great options. [Which patient] do we choose for which agent?” said Woyach.

December 2019 Foundation Update:  Holiday Edition

Originally Published: 12/20/2019

Symptomatic Heart Failure in Acute Leukemia Patients Treated With Anthracyclines

Originally Published: 12/17/2019
Objectives The purpose of this study was to investigate the occurrence and develop a risk score for heart failure (HF) in acute leukemia.

ASH 2019: Can Rapid Precision Medicine Help Older Adults With AML?

Originally Published: 12/07/2019
When someone is diagnosed with acute myeloid leukemia (AML), doctors typically initiate treatment within 24-48 hours of diagnosis given the aggressive nature of the disease. This urgency to treat precludes the use of ancillary test results, such as genomic profiling, to guide upfront treatment decision making and clinical management. Yet, understanding the genomic alterations associated with a patient’s disease is critical and can help enable oncologists to identify the most effective, targeted treatment options. (con't)

Allogeneic Hematopoietic Cell Transplantation and Other Expensive Cellular Therapies: A Miracle for the Few but Off Limits to Many?

Originally Published: 11/15/2019
The number of patients undergoing allogeneic hematopoietic cell transplantation (HCT) for treatment of malignant and nonmalignant disorders has continued to grow worldwide. (footnotes) Great progress has been made in overcoming HLA/immunologic barriers, but nondonor barriers to HCT persist.(footnote) This represents a major unmet need because HCT is not accessible to everyone who would benefit from it.(footnote)

November 2019 AAMDSIF Update Newsletter

Originally Published: 11/14/2019

Summer 2019 MDS Update

Originally Published: 11/08/2019
Read the latest in what's happening in MDS research, hear from MDS patients and so much more! 

Genomic Biomarkers to Predict Resistance to Hypomethylating Agents in Patients With Myelodysplastic Syndromes Using Artificial Intelligence

Originally Published: 10/29/2019
We developed an unbiased framework to study the association of several mutations in predicting resistance to hypomethylating agents (HMAs) in patients with myelodysplastic syndromes (MDS), analogous to consumer and commercial recommender systems in which customers who bought products A and B are likely to buy C: patients who have a mutation in gene A and gene B are likely to respond or not respond to HMAs.

Dr. Babushok on Treatment Advances in Paroxysmal Nocturnal Hemoglobinuria

Originally Published: 10/24/2019
Daria V. Babushok, MD, PhD, an assistant professor of medicine, Perelman School of Medicine, University of Pennsylvania, discusses treatment advances in paroxysmal nocturnal hemoglobinuria (PNH).