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Summary
Many veterans and doctors have long questioned whether Agent Orange (AO) exposure during the Vietnam War contributed to cases of myelodysplastic syndrome (MDS), a type of blood cancer.
The contaminated chemical is linked to several cancers, but a link to MDS was unclear. This created real barriers for exposed veterans with MDS who are seeking care and disability benefits.
Key points
Outpatient low-dose VenAza plus itraconazole reduced early mortality and hospitalizations while maintaining treatment efficacy.
Highlights
Heme biosynthesis enzymes are variably suppressed in AML
Heme levels are linked with altered leukemic transcriptional programs via BACH1
Heme biosynthesis is a selective dependency in AML, both in vitro and in vivo
Heme starvation disrupts complex IV, inducing copper accumulation and cuproptosis
Abstract
Key Points
Ivosidenib, venetoclax ± azacitidine either rapidly selects evolved, resistant leukemic clones or eradicates leukemic clones.
Resistant clones express RNA signatures of stemness, branched-chain amino acid metabolism, and menin targets.
Dr. Eileen Hu is an internal medicine specialist located in Dallas, TX, who completed her education at Ohio State University College of Medicine in 2022 and is currently undergoing her residency in internal medicine at the University of Texas Southwestern Medical Center, projected to finish in 2028. She has contributed to several publications focusing on leukemia, including works in Nature Genetics, Cell Reports, and Blood, with citations indicating engagement from the scientific community.
Dr. Jamie Koprvinikar specializes in hematology and medical oncology and is board certified in both. She also holds a board certification in internal medicine.
Geordy’s youth was an active one. Baseball, Soccer, and Hockey filled his days, even competing in the Little League World Series!
He was active in his family’s church, too. When offered the opportunity to go on a Youth with a Mission (YWAM) program to Australia, he traveled from his home in British Columbia to participate. Once there, the spark of ministry became a calling, so he attended college in Saskatchewan to become a pastor.
Clayton Jackson, M.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center. He specializes in hematology and oncology.