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Grant Year: 2025

The most serious complication for people with severe aplastic anemia aplastic anemia: (ay-PLASS-tik uh-NEE_mee-uh) A rare and serious condition in which the bone marrow fails to make enough blood cells - red blood cells, white blood cells, and platelets. The term aplastic is a Greek word meaning not to form. Anemia is a condition that happens when red blood cell count is low. Most… (SAA) after receiving immune-suppressive treatment, with or without the drug eltrombopag eltrombopag: What are the possible side effects of eltrombopag (Promacta)? Get emergency medical help…

Dr. Tessier is a clinician-scientist in training at Mayo Clinic with a career goal of leading research focused on high risk blood cancers, particularly myeloid neoplasms (MN) and leukemia. These cancers often carry genetic changes that make them resistant to treatment. Among the most aggressive and challenging of these are MN with mutations in the TP53 gene (TP53mut), which are associated with rapid disease progression, resistance to all available leukemia therapies, and extremely poor survival. TP53mut MN account for up to 40% of therapy-related MN, a devastating scenario in which patients…

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