Where There's Smoke, There's Fire: Inflammation Drives MDS | Aplastic Anemia and MDS International Foundation (AAMDSIF) Return to top.

Where There's Smoke, There's Fire: Inflammation Drives MDS

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Journal Title: 
Trends in immunology
Primary Author: 
Gandhar K Datar
Author(s): 
Gandhar K Datar, Margaret A Goodell
Original Publication Date: 
Wednesday, July 1, 2020
Full Article on PubMed: 
https://www.ncbi.nlm.nih.gov/pubmed/32513619/
Bone Marrow Disease(s): 

Chronic inflammation has been implicated in myelodysplastic syndrome (MDS); however, its role in disease progression is unclear. In a new study by Muto et al., MDS stem cells sparked with TRAF6-activated innate immune signaling were found to outcompete normal counterparts only when fueled by environmental inflammatory stimuli. Non-canonical NF-κB signaling is implicated in inflammatory synergy and MDS progression.