T-cell dysfunctions in myelodysplastic syndromes | Aplastic Anemia and MDS International Foundation (AAMDSIF) Return to top.

T-cell dysfunctions in myelodysplastic syndromes

Journal Title: 
Primary Author: 
Rodriguez-Sevilla JJ, Colla S
Rodriguez-Sevilla JJ, Colla S
Original Publication Date: 
Thursday, April 4, 2024
Bone Marrow Disease(s): 

Escape from immune surveillance is a hallmark of cancer. Immune deregulation caused by intrinsic and extrinsic cellular factors, such as altered T-cell functions, leads to immune exhaustion, loss of immune surveillance, and clonal proliferation of tumoral cells. The T-cell immune system contributes to the pathogenesis, maintenance, and progression of myelodysplastic syndrome (MDS). Here, we comprehensively reviewed our current biological knowledge of the T-cell compartment in MDS and recent advances in the development of immunotherapeutic strategies, such as immune checkpoint inhibitors and T-cell- and antibody-based adoptive therapies that hold promise to improve the outcome of patients with MDS.