Role of innate immunological/inflammatory pathways in myelodysplastic syndromes and AML: a narrative review | Aplastic Anemia & MDS International Foundation Return to top.

Role of innate immunological/inflammatory pathways in myelodysplastic syndromes and AML: a narrative review

Journal Title: 
Experimental Hematology & Oncology
Primary Author: 
Vegivinti CTR
Author(s): 
Vegivinti CTR, Keesari PR, Veeraballi S, Martins Maia CMP, Mehta AK, Lavu RR, Thakur RK, Tella SH, Patel R, Kakumani VK, Pulakurthi YS, Aluri S, Aggarwal RK, Ramachandra N, Zhao R, Sahu S, Shastri A, Verma A
Original Publication Date: 
Saturday, July 8, 2023

Dysregulation of the innate immune system and inflammatory-related pathways has been implicated in hematopoietic defects in the bone marrow microenvironment and associated with aging, clonal hematopoiesis, myelodysplastic syndromes (MDS), and acute myeloid leukemia (AML). As the innate immune system and its pathway regulators have been implicated in the pathogenesis of MDS/AML, novel approaches targeting these pathways have shown promising results. Variability in expression of Toll like receptors (TLRs), abnormal levels of MyD88 and subsequent activation of NF-κβ, dysregulated IL1-receptor associated kinases (IRAK), alterations in TGF-β and SMAD signaling, high levels of S100A8/A9 have all been implicated in pathogenesis of MDS/AML. In this review we not only discuss the interplay of various innate immune pathways in MDS pathogenesis but also focus on potential therapeutic targets from recent clinical trials including the use of monoclonal antibodies and small molecule inhibitors against these pathways.

Keywords: Acute myeloid leukemia (AML); IL1 receptor Associated kinase (IRAK); Inflammasome; Innate Immune pathways; Myelodysplastic syndromes (MDS); Toll like receptors (TLRs); Tumor microenvironment (TME).

Bone Marrow Disease(s): 
  • myelodysplastic syndromes (MDS)
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