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Consider Allogeneic Bone Marrow Transplantation for Older, Fit Patients with Aplastic Anemia

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Journal Title: 
Biol Blood Marrow Transplant
Primary Author: 
Georges GE
Author(s): 
Georges GE
Original Publication Date: 
Friday, January 11, 2019
Full Article on PubMed: 
https://www.ncbi.nlm.nih.gov/pubmed/30641134/
Bone Marrow Disease(s): 
Effective treatment for severe aplastic anemia (SAA) is either allogeneic bone marrow transplantation (BMT) [1,2] or nontransplant immunosuppressive therapy (IST) containing antithymocyte globulin (ATG) [3,4]. Both treatment approaches have advanced over the recent decades to achieve significantly improved outcomes. Considering that allogeneic BMT is a more durable treatment with a reduced risk of long-term complications and improved overall survival compared with IST, there is widespread consensus that BMT is the preferred first-line therapy for younger patients with SAA who have an HLA-matched sibling donor [1].