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Key PointsIn first-line therapy of MAA patients, CSA+eltrombopag significantly improves ORR at 24 weeks compared to CSA+placebo (71% vs. 43%; p=0.011)Addition of
eltrombopag
eltrombopag:
What are the possible side effects of eltrombopag (Promacta)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips…
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AbstractCalreticulin (CALR) frameshift mutations drive the majority of JAK2/MPL-wild-type cases of essential thrombocythemia and myelofibrosis, producing a shared novel C-terminus that activates the thrombopoietin receptor and leads to constitutive Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling. CALR mutations transform the multifunctional…
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Relapse is the leading cause of allogeneic hematopoietic stem cell transplant (allo-HSCT) failure in myeloid neoplasms [1]. Patients receiving reduced-intensity conditioning (RIC) regimens have a higher risk of post-transplant relapse compared to those undergoing myeloablative conditioning (MAC) [2]. However, many patients are not candidates for MAC due to age, comorbidities, or frailty.…
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Abstract
Hypocellular
Hypocellular:
A condition in which there are too few cells, for example, within the bone marrow. Patients with aplastic anemia have hypocellular bone marrow.
bone marrow failure
bone marrow failure:
A condition that occurs when the bone marrow stops making enough healthy blood cells. The most common of these rare diseases are aplastic…
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Key PointsStag2 reprograms Gata1 cistrome specificity via chromatin accessibility, a key determinant of transcription factor lineage discrimination.Loss of the Stag2 rheostat causes accessibility-driven Gata1 retargeting, providing a mechanistic framework for dyserythropoiesis in MDS.AbstractThe transcription factor GATA1 has pleiotropic hematopoietic functions,…
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Key PointsZiftomenib shows pronounced preclinical activity in the menin-KMT2A–dependent leukemia models, including patient-derived xenografts.Ziftomenib demonstrates potent activity against a subset of the drug-induced MEN1 mutations found in patients with
acute myeloid leukemia
acute myeloid leukemia:
(uh-KYOOT my-uh-LOYD loo-KEE-mee-uh) A cancer of the blood cells. It…
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HighlightsReduced cumulative post-transplant
cyclophosphamide
cyclophosphamide:
Cyclophosphamide is in a class of medications called alkylating agents. When used to treat cancer, it works by slowing or stopping the growth of cancer cells in your body. When cyclophosphamide is used to treat bone marrow failure, it works by suppressing your body's immune system.
(<…
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Key PointsMLL3 and MLL4 act redundantly in HSCs to sustain transcription factor and enhancer networks that support multipotency.Simultaneous loss of MLL3 and MLL4 drives hematopoietic progenitors into a uniform B-cell–like default state.AbstractHematopoietic
stem cells
stem cells:
Cells in the body that develop into other cells. There are two main…
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Key PointsPosttransplant
cyclophosphamide
cyclophosphamide:
Cyclophosphamide is in a class of medications called alkylating agents. When used to treat cancer, it works by slowing or stopping the growth of cancer cells in your body. When cyclophosphamide is used to treat bone marrow failure, it works by suppressing your body's immune system.
significantly reduced GVHD…
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ABSTRACTIntroductionCentral venous catheter (CVC) insertion is frequently required in patients with haematological diseases. Despite limited evidence,
thrombocytopenia
thrombocytopenia:
(throm-buh-sie-tuh-PEE-nee-uh) A condition in which there is a shortage of platelets in the bloodstream. This results in a low platelet count. Bleeding and bruising…
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AbstractMyeloproliferative neoplasms (MPNs) were previously thought to result solely from somatic mutations; however, familial clustering and germline genetic testing have revealed hereditary MPNs. These hereditary MPNs are one type of hereditary hematopoietic malignancy (HHM) syndrome, or hereditary blood cancer, and generally display an autosomal-dominant inheritance pattern…
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Key PointscHSPCTrack uses circulated human HSPCs to reconstruct clonal differentiation dynamicsHuman HSPCs clones differentiation varies stochastically in lineage output and differentiation rate even in controlled isolated environmentsHematopoietic stem and progenitor cells (HSPCs) balance self-renewal with on-demand differentiation of blood lineages. Modern
bone marrow…
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AbstractPurposeThe Children's Oncology Group phase III
clinical trial
clinical trial:
A type of research study that tests how a drug, medical device, or treatment approach works in people. There are several types of clinical trials. Treatment trials test new treatment options. Diagnostic trials test new ways to diagnose a disease. Screening trials test…
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Key PointsChronic inflammation promotes transient myeloid differentiation in Tet2-deficient HSPCs, but accelerates HSC exhaustion and MDS development.NLRC4 inflammasome activation drives this process; Nlrc4 deletion delays MDS development and improves survival in Tet2-deficient mice.
Myelodysplastic syndromes
Myelodysplastic syndromes:
(my-eh-lo-diss-PLASS-tik SIN-…
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AbstractPOEMS syndrome is a rare multisystem
plasma
plasma:
The fluid part of the blood. Plasma is mostly made of water with chemicals in it. These chemicals include proteins, hormones, minerals, and vitamins.
cell disorder for which evidence guiding management is largely derived from single-center retrospective series. We conducted a retrospective multicenter study…
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IntroductionPayers employ health care utilization–management strategies, including prior authorization (PA), to limit costs and promote evidence-based, guideline-concordant care. However, PA may be inconsistently applied and associated with patient confusion and frustration.1-3 Patient engagement in PA processes can add to administrative burden and may be associated with adverse…
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Hypomethylating agents–venetoclax as salvage therapy for relapse of AML and MDS after allogeneic HCT
Key PointsHMA-VEN is well tolerated in patients with AML/MDS who relapsed after alloHCT.HMA-VEN is effective for relapsed AML/MDS after alloHCT, even in patients who have failed prior VEN-based regimens.AbstractRelapse after allogeneic hematopoietic cell transplantation (alloHCT) remains a challenge for patients with
acute myeloid leukemia
acute myeloid…
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Background: Philadelphia-negative myeloproliferative neoplasms (MPNs), including essential thrombocythaemia (ET), polycythaemia vera (PV), and myelofibrosis (MF), usually affect older adults, but a subset occurs in adolescents and young adults (AYA). Regional age-stratified data remain limited.
Methods: We retrospectively studied Philadelphia-negative MPN patients managed at the National Center…
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Highlights -Considerable heterogeneity exists in germline testing implementation across hematopoietic stem cell transplantation centers in the United States.-Lack of standardized protocols affects the timing of testing and inconsistent sample collection workflows.-Barriers to consistent care include insurance challenges, logistical constraints, and…
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Key PointsPRCA shows marked diagnostic heterogeneity, where molecular data can help identify challenging secondary forms, such as MDS-associated cases.Early initiation of CyA improves outcomes; mTORi are valuable second-line treatment. Infection related mortality remains non negligible.Abstract
Pure red cell aplasia (PRCA)
Pure red cell aplasia (PRCA):
A…
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