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CONFERENCE LOCATION:Heldrich Hotel 10 Livingston AvenueNew Brunswick, NJ 08901Parking: Complimentary hotel valet parking CONFERENCE AGENDA
Aplastic Anemia
Aplastic Anemia:
(ay-PLASS-tik uh-NEE_mee-uh) A rare and serious condition in which the bone marrow fails to make enough blood cells - red blood cells, white blood cells, and platelets. The term aplastic is a Greek…
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VEXAS syndrome is a clonal hemato-inflammatory disorder impacting older, predominantly male patients, characterized by systemic inflammation and progressive
bone marrow failure
bone marrow failure:
A condition that occurs when the bone marrow stops making enough healthy blood cells. The most common of these rare diseases are aplastic anemia, myelodysplastic syndromes (MDS) and…
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SummaryDonor cell-derived haematological neoplasms (DDHN) are rare disorders and currently do not have standardised diagnostic criteria and therapeutic management. International experts in allogeneic transplantation and haematological malignancies from Europe, the Americas, and Australia worked together on behalf of the EBMT Practice Harmonisation and Guidelines Committee to delineate a pragmatic…
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HighlightsIn lower-risk MDS subgroup, trisomy 8 and 9 were more frequent in MDS-AID.MDS-AID had fewer tier 1 or 2 mutations than MDS-control or MDS-ALE.ASXL1 mutations were enriched in MDS-ALE within lower-risk MDS.No significant differences in OS or PFS versus MDS-control.IPSS-M was the only variable independently associated with outcomes. AbstractBackgroundAutoimmune features are…
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The timing of TP53
mutation
mutation:
Any change or alteration in a gene. A mutation may cause disease or may be a normal variation. Paroxysmal nocturnal hemoglobinuria (PNH) occurs because of a mutation in the PIG-A gene of a single stem cell in the bone marrow.
acquisition carries important prognostic implications for patients with myeloproliferative neoplasms (MPNs) and…
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A blood cancer survivor debunks the movie myth of a quick cure, exposing the harsh, lasting side effects that remain after ringing the bell.One phrase I get tired of hearing lately is that something is a process. This word is often over-used and applies to anything from life crisis to learning how to cook! However, now I am going to used that phrase.Movies are fictional, and we all know…
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TP53-mutated (TP53-mt)
myelodysplastic syndromes
myelodysplastic syndromes:
(my-eh-lo-diss-PLASS-tik SIN-dromez) A group of disorders where the bone marrow does not work well, and the bone marrow cells fail to make enough healthy blood cells. Myelo refers to the bone marrow. Dysplastic means abnormal growth or development. People with MDS have low blood cell count for at…
(MDS) are…
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Highlight
The 10-year incidence of non-cutaneous SM (6.8%) confirms its impact on late NRM.
SM subtype distribution and timing vary by transplant: t-MDS/AML after auto-HCT, PTLD early after allo-HCT.
PTLD declined markedly, nearly disappearing in the PTCy era with less ATG/Cord blood.
PTCy-based GVHD prophylaxis was not linked to higher solid tumor risk.
Abstract
Background
Secondary malignancies…
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Abstract
6508
Background: Advances in hematopoietic stem cell transplantation (HSCT) have been driven by progress in
supportive care
supportive care:
Care given to improve the quality of life, or comfort, of a person with a chronic illness. Supportive care treats the symptoms rather than the underlying cause of a disease. The goal is to help the patient feel better. Patients with low…
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Haploidentical
bone marrow
bone marrow:
The soft, spongy tissue inside most bones. Blood cells are formed in the bone marrow.
transplantation (haplo-BMT) with post-transplant
cyclophosphamide
cyclophosphamide:
Cyclophosphamide is in a class of medications called alkylating agents. When used to treat cancer, it works by slowing or stopping the growth of cancer cells in your…
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Abstract
Background
We aimed to study outcomes of allogeneic hematopoietic cell transplantation in
acute myeloid leukemia
acute myeloid leukemia:
(uh-KYOOT my-uh-LOYD loo-KEE-mee-uh) A cancer of the blood cells. It happens when very young white blood cells (blasts) in the bone marrow fail to mature. The blast cells stay in the bone marrow and become to numerous. This slows production of…
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Abstract
Purpose of Review
In inherited
bone marrow failure
bone marrow failure:
A condition that occurs when the bone marrow stops making enough healthy blood cells. The most common of these rare diseases are aplastic anemia, myelodysplastic syndromes (MDS) and paroxysmal nocturnal hemoglobinuria (PNH). Bone marrow failure can be acquired (begin any time in life) or can be…
syndromes…
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Key Points
Timely manufacture of VCAR33, a donor-derived CD33-directed CAR T, was feasible in patients with relapsed/refractory AML after alloHCT.
VCAR33 had an acceptable safety profile at doses up to 3 × 106 cells/kg and demonstrated antileukemic activity with a response rate of 20%.
Abstract
VCAR33, a donor-derived CD33-directed chimeric antigen receptor T-cell (CAR T) product, was developed…
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Correspondence
The Myelodysplastic/Myeloproliferative neoplasm (MDS/MPN) overlap syndromes are a heterogeneous group of rare hematologic malignancies characterized by features of both MDS such as morphologic dysplasia and cytopenias and MPNs including elevated blood counts and often splenomegaly [1]. These syndromes frequently harbor recurrent mutations, underscoring their interrelated biological…
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Key Points:
Many patients and caregivers associate early palliative care (EPC) with hospice or death, a misperception that may persist even after gaining a better understanding of the role of EPC and may prevent them from experiencing the benefits of EPC.
Cultural or religious beliefs about illness and death may further influence views of EPC, and clinicians must engage in culturally sensitive…
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Abstract
Allogeneic hematopoietic cell transplantation (ASCT) is the only curative option for patients with
myelodysplastic syndromes
myelodysplastic syndromes:
(my-eh-lo-diss-PLASS-tik SIN-dromez) A group of disorders where the bone marrow does not work well, and the bone marrow cells fail to make enough healthy blood cells. Myelo refers to the bone marrow. Dysplastic means abnormal…
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