Lisa J. McReynolds, M.D., Ph.D., joined the Clinical Genetics Branch (CGB) as a clinical fellow in 2016, was promoted to assistant clinical investigator in 2019 and became a Lasker Clinical Research Clinical Research: A type of research that involves individual persons or a group of people. There are three types of clinical research. Patient-oriented research includes clinical trials which test how a drug, medical device, or treatment approach works in people. Epidemiology or behavioral studies look at the… Scholar in 2024. She earned her M.D. and Ph.D. at Albert Einstein College of Medicine, where she studied Smad signaling in a zebrafish model of hematopoiesis hematopoiesis: (hi-mat-uh-poy-EE-suss) The process of making blood cells in the bone marrow. in the laboratory of Todd Evans, Ph.D. (2009). Dr. McReynolds then completed a residency in pediatrics at Morgan Stanley’s Children’s Hospital of New York-Presbyterian Hospital and fellowship through the joint program of Johns Hopkins University and NCI. Before joining CGB, she worked at the National Institute of Allergy and Infectious Diseases (NIAID) as a clinical and postdoctoral research fellow in the laboratory of Dr. Steven Holland. At NIAID, her research focused on GATA2 deficiency, an inherited bone marrow failure bone marrow failure: A condition that occurs when the bone marrow stops making enough healthy blood cells. The most common of these rare diseases are aplastic anemia, myelodysplastic syndromes (MDS) and paroxysmal nocturnal hemoglobinuria (PNH). Bone marrow failure can be acquired (begin any time in life) or can be… and immunodeficiency disorder caused by germline variation in GATA2, a gene essential to hematopoiesis and vascular development. As a clinical fellow under the mentorship of Sharon A. Savage, M.D., Director and senior investigator, CGB, she focused on gene discovery and genome characterization in marrow failure patients in the inherited bone marrow failure cohort. She received the DCEG Intramural Research Award in 2017 and an NIH Director's Award as part of the NIH COVID Vaccine and Booster Clinic Team in 2022.
Bethesda, MD 20892
United States