Key Points
SRSF2 mutations blunt responsiveness of MDS cells to IFN stimulation and promote their clonal fitness by downregulating STAT1 expression
Proteasome inhibition restores STAT1 protein level and sensitivity of SRSF2-mutant MDS cells to IFN, suggesting a new therapeutic strategy
Abstract
CONFERENCE AGENDA - September 27, 2025
(Eastern Time Zone)
CONFERENCE AGENDA - October 18, 2025
(Eastern Time Zone)
Join us in Verona Park, NJ on Sunday, September 28, 2025 for a day of remembrance and awareness in celebration of the 19th Annual Walk for PNH.
The Walk for PNH is the nation's largest event to raise awareness and funds for PNH education and research. This inspiring event calls on participants of all ages and abilities to join in the fight against PNH.
As we prepare for the upcoming golf tournament, benefiting AAMDSIF a nonprofit organization that helps people living with PNH, it is with a heart full of fond memories that we take a moment to reflect on Kim, whose spirit truly embodied kindness and positivity. She always had a smile on her face, uplifting everyone around her, even on challenging days.
Hack for Marrow is a week-long global hackathon designed for teenagers aged 13 to 19. Whether you're a passionate coder or exploring programming for the first time, we’d love to have you join us!
Participants may compete individually or in teams of up to three members. To register, simply click the “Register” button above to sign up as an individual or with your team.
Judy talks about her PNH journey from diagnosis, treatment decisions and moving forward.
In this recording, Dr. Srinivasa Sanikommu discusses current thinking on PNH and therapies that are available to patients. Recording includes the question-and-answer session.
In this recording, Dr. Srinivasa Sanikommu discusses PNH complications that can impact a patient - extravascular hemolysis, intravascular hemolysis,