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graft versus host disease (GVHD)

Epigenetic Aging and Hematopoietic Cell Transplantation in Patients With Severe Aplastic Anemia

Author(s): 
Alsaggaf R, Katta S, Wang T, Hicks BD, Zhu B, Spellman SR, Lee SJ, Horvath S, Gadalla SM
Primary Author: 
Alsaggaf R
Journal Title: 
Transplantation and Cellular Therapy
Original Publication Date: 
Apr 2021

Cellular aging in hematopoietic cell transplantation (HCT) is important in the context of immune reconstitution and age-related complications. Recently, several DNA-methylation (DNAm)-based biomarkers of aging known as "epigenetic clocks" have been introduced as novel tools to predict cellular age.

Transplant Virtual Support Group

Event Date: 
Wed, 02/16/2022 - 5:30pm (EST)

AAMDSIF is pleased to announce that we will host a support group for patients who have been treated with a transplant, or who are considering having a transplant. The group is hosted by AAMDSIF and will be monitored to ensure the privacy and safety of our participants. 

Young Adult Virtual Support Group

Event Date: 
Mon, 11/22/2021 - 7:00pm (EST)

This virtual support group is to help support patients between the ages of 18-30 who have been diagnosed with

Trading One Disease for Another: Patients With Chronic Graft-vs-Host Disease May Face Lifelong Complications

The field of allogeneic stem cell transplantation continues to improve survival for patients with previously incurable blood cancers. However, up to 50% of patients who undergo transplantation with donor cells will develop chronic graft-vs-host disease, a potentially deadly condition that can also cause lifelong complications.

James Cook, MD, PhD

MD, PhD Cook, James
Professor of Pathology
Cleveland Clinic, Learner School of Medicine

James R. Cook, M.D., Ph.D., is a Professor of Pathology at the Cleveland Clinic Lerner College of Medicine.  He serves as Section Head of Hematopathology in the Department of Laboratory Medicine.  Dr. Cook's clinical interests focus on diagnostic hematopathology and molecular diagnostics.

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