paroxysmal nocturnal hemoglobinuria (PNH) | Page 28 | Aplastic Anemia & MDS International Foundation

paroxysmal nocturnal hemoglobinuria (PNH)

Seroreactivity to LGL leukemia-specific epitopes in aplastic anemia, myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria: results of a bone marrow failure consortium study.

Author(s): 
Nyland SB, Krissinger DJ, Clemente MJ, Irby RB, Baab KT, Jarbadan NR, Sokol L, Schaefer E, Liao J, Cuthbertson D, Epling-Burnette P, Paquette R, List AF, Maciejewski JP, Loughran TP Jr.
Primary Author: 
Nyland SB
Journal Title: 
Leuk Res
Original Publication Date: 
Mar 2012

Large granular

Paroxysmal nocturnal hemoglobinuria in pediatric patients.

Author(s): 
Curran KJ, Kernan NA, Prockop SE, Scaradavou A, Small TN, Kobos R, Castro-Malaspina H, Araten D, Dimichele D, O'Reilly RJ, Boulad F
Primary Author: 
Curran KJ
Journal Title: 
Pediatr Blood Cancer
Original Publication Date: 
Dec 2011

BACKGROUND:

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disease in children. The most significant clinical features of PNH include: bone marrow failure, intravascular hemolysis, and thrombosis. To further characterize the clinical presentation and outcome to treatment we performed a retrospective analysis of pediatric patients with PNH.

PROCEDURE:

We reviewed the medical records of 12 consecutive pediatric patients with PNH diagnosed at our institution from 1992 to 2010.

RESULTS:

Paroxysmal nocturnal hemoglobinuria and pregnancy before the eculizumab era: the French experience

Author(s): 
de Guibert S, Peffault de Latour R, Varoqueaux N, Labussière H, Rio B, Jaulmes D, Eveillard JR, Dulucq S, Stoppa AM, Bouscary D, Girodon F, Bonnotte B, Laskri D, Socié G, Lamy T.
Primary Author: 
de Guibert S
Journal Title: 
Haematologica
Original Publication Date: 
May 2011

Background Pregnancy in women with

Chronic treatment of paroxysmal nocturnal hemoglobinuria patients with eculizumab: safety, efficacy, and unexpected laboratory phenomena

Author(s): 
Röth A, Hock C, Konik A, Christoph S, Dührsen U
Primary Author: 
Röth A
Journal Title: 
Int J Hematol.
Original Publication Date: 
May 2011

The terminal complement inhibitor