Paroxysmal Nocturnal Hemoglobinuria (PNH)
Ninth International Bone Marrow Failure Disease Scientific Symposium
Medical Jargon Made Simple
Caregivers: What to Expect When Your Loved One is Diagnosed
Biosimilars - Treatment Options for Patients
Extravascular Hemolysis and PNH
Volunteer
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Predictors for improvement in patient-reported outcomes: post hoc analysis of a phase 3 randomized, open-label study of eculizumab and ravulizumab in complement inhibitor-naive patients with paroxysmal nocturnal hemoglobinuria
Paroxysmal nocturnal hemoglobinuria Paroxysmal nocturnal hemoglobinuria: (pa
Clonal Hematopoiesis, Inflammation, and Hematologic Malignancy
Somatic or acquired mutations are postzygotic genetic variations that can occur within any tissue. These mutations accumulate during aging and have classically been linked to malignant processes. Tremendous advancements over the past years have led to a deeper understanding of the role of somatic mutations in benign and malignant age-related diseases. Here, we review the somatic mutations that accumulate in the blood and their connection to disease states, with a particular focus on inflammatory diseases and myelodysplastic syndrome.