paroxysmal nocturnal hemoglobinuria (PNH) | Page 25 | Aplastic Anemia & MDS International Foundation

paroxysmal nocturnal hemoglobinuria (PNH)

Selective splenic artery embolization for the treatment of thrombocytopenia and hypersplenism in paroxysmal nocturnal hemoglobinuria

Author(s): 
Araten DJ, Iori AP, Brown K, Torelli GF, Barberi W, Natalino F, De Propris MS, Girmenia C, Salvatori FM, Zelig O, Foà R, Luzzatto L
Primary Author: 
Araten DJ
Journal Title: 
J Hematol Oncol
Original Publication Date: 
Mar 2014

BACKGROUND:

PNH is associated with abdominal vein thrombosis, which can cause splenomegaly and hypersplenism. The

Bone Marrow Diseases: 

Baseline characteristics and disease burden in patients in the international paroxysmal nocturnal hemoglobinuria registry

Author(s): 
Schrezenmeier H, Muus P, Socié G, Szer J, Urbano-Ispizua A, Maciejewski JP, Brodsky RA, Bessler M, Kanakura Y, Rosse W, Khursigara G, Bedrosian C, Hillmen P
Primary Author: 
Schrezenmeier H
Journal Title: 
Haematologica
Original Publication Date: 
Jan 2014

Bone Marrow Diseases: 

Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

Author(s): 
Risitano AM, Ricklin D, Huang Y, Reis ES, Chen H, Ricci P, Lin Z, Pascariello C, Raia M, Sica M, Del Vecchio L, Pane F, Lupu F, Notaro R, Resuello RR, Deangelis RA, Lambris JD
Primary Author: 
Risitano AM
Journal Title: 
Blood
Original Publication Date: 
Feb 2014

Bone Marrow Diseases: 

Improving cytopenia with splenic artery embolization in a patient with paroxysmal nocturnal hemoglobinuria on eculizumab

Author(s): 
Krishnan SK, Hill A, Hillmen P, Arnold LM, Brooksbank GL, Wood A, Scarsbrook A, Davies MH, Kelly RJ
Primary Author: 
Krishnan SK
Journal Title: 
Int J Hematol
Original Publication Date: 
Dec 2013

Bone Marrow Diseases: 

A prospective multicenter study of paroxysmal nocturnal hemoglobinuria cells in patients with bone marrow failure.

Author(s): 
Raza A, Ravandi F, Rastogi A, Bubis J, Lim SH, Weitz I, Castro-Malaspina H, Galili N, Jawde RA, Illingworth A.
Primary Author: 
Raza A
Journal Title: 
Cytometry B Clin Cytom
Original Publication Date: 
Nov 2013

BACKGROUND:
Paroxysmal nocturnal hemoglobinuria (PNH), a rare clonal hematopoietic stem cell disorder, is characterized by chronic, uncontrolled complement activation leading to intravascular hemolysis and an inflammatory prothrombotic state. The EXPLORE study aimed to determine the prevalence of undiagnosed PNH in patients with aplastic anemia (AA), myelodysplastic syndrome (MDS), and/or other bone marrow failure (BMF) syndromes and the effect of PNH clone size on hemolysis.
METHODS:
Patients, selected from medical office chart reviews, had blood samples collected for hematologic panel testing and for flow cytometry detection of PNH clones.
RESULTS:

Bone Marrow Diseases: