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paroxysmal nocturnal hemoglobinuria (PNH)

James Cook, MD, PhD

MD, PhD Cook, James
Professor of Pathology
Cleveland Clinic, Learner School of Medicine

James R. Cook, M.D., Ph.D., is a Professor of Pathology at the Cleveland Clinic Lerner College of Medicine.  He serves as Section Head of Hematopathology in the Department of Laboratory Medicine.  Dr. Cook's clinical interests focus on diagnostic hematopathology and molecular diagnostics.

We Made It! – Kristy Shares her Perspective in January 2021

Person's Name: 
Kristy Maliczowski

We made it to another treatment day without anyone in our family getting sick! The week leading to treatment day has become pretty worrisome for me. What if someone in our family gets sick with or is exposed to COVID? Josh will not be able to get his infusion within the treatment window and then what? The questions I never thought I'd have to wonder about. I used to dread treatment day because it was a reminder that Josh has

Content source: 

Is blood transfusion safe during the COVID-19 pandemic?

Author(s): 
Josiane Bassil, Elie Rassy, Joseph Kattan
Primary Author: 
Bassil J
Journal Title: 
Future Science OA
Original Publication Date: 
Sep 2020

The rapid spread of the coronavirus disease 2019 (COVID-19) pandemic has challenged healthcare systems to re-organize the management of patients in a short period. The causative pathogen of this pandemic is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), one of seven coronaviruses that can be found in humans. It is a rapidly mutating, enveloped, ssRNA, beta-coronavirus. The initial reports published after the pandemic spread showed a transmissibility rate of 2.2 and possibly low values of dispersion.

Severe Aplastic Anemia and PNH Diagnoses Came out of Nowhere - Marianna's Story

Person's Name: 
Marianna De Leon

As a typical community college student, Mariana was busy. Classes, studying, day trips, all were part of her life. Yet during one shower, she dropped to the floor, suddenly dizzy. A few weeks later she would be out of breath, with unusual bruises on her skin.

Content source: 

One-year outcomes from a phase 3 randomized trial of ravulizumab in adults with paroxysmal nocturnal hemoglobinuria who received prior eculizumab

Author(s): 
Kulasekararaj AG, Hill A, Langemeijer S, Wells R, González Fernández FA, Gaya A, Ojeda Gutierrez E, Piatek CI, Mitchell L, Usuki K, Bosi A, Brodsky RA, Ogawa M, Yu J, Ortiz S, Röth A, Lee JW, Peffault de Latour R.
Primary Author: 
Kulasekararaj AG
Journal Title: 
European Journal of Haematology
Original Publication Date: 
Dec 2020

Ravulizumab every 8 weeks showed non-inferiority to

Frequency and perturbations of various peripheral blood cell populations before and after eculizumab treatment in paroxysmal nocturnal hemoglobinuria

Author(s): 
Gurnari C, Graham AC, Efanov A, Pagliuca S, Durrani J, Awada H, Patel BJ, Lichtin AE, Visconte V, Sekeres MA, Maciejewski JP
Primary Author: 
Gurnarci C
Journal Title: 
Blood, cells, molecules & diseases
Original Publication Date: 
Dec 2020

While red blood cells (RBCs) and granulocytes have been more studied, platelets and reticulocytes are not commonly used in

Paroxysmal nocturnal hemoglobinuria: role of the complement system, pathogenesis, and pathophysiology

Author(s): 
Meryem Bektas, Catherine Copley-Merriman, Shahnaz Khan, Sujata P Sarda, Jamile M Shammo
Primary Author: 
Bektas, M
Journal Title: 
Journal of Managed care and specialty pharmacy
Original Publication Date: 
Dec 2020

The complement system is part of the innate immune response system, which comprises more than 50 distinct

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