Clinical Trial If you are interested in learning more about your possible participation in this clinical trial, please complete the form. Your information will be forwarded directly to the trial sponsor.
This is a Phase II study of hematopoietic stem cell transplantation for previously untreated patients with severe aplastic anemia. This study is comprised of two cohorts - patients receiving haploidentical donor transplant and patients receiving unrelated donor transplant. The goal is to enroll 60 participants total, 30 in each cohort.
Patients with a diagnosis of Severe Aplastic Anemia who do not have a fully HLA-matched related sibling donor who have not received any prior treatment. Patients need to have adequate organ function to be able to tolerate a reduced-intensity hematopoietic cell transplant.
Patients with Inherited or Congenital Bone Marrow Failure Syndromes are not eligible for this study. Patients cannot have received previous treatment for Aplastic Anemia and cannot have inadequate organ function, uncontrolled infection, or have received a prior solid organ transplant. Patients who are pregnant are not eligible for hematopoietic cell transplantation.