Factors affecting treatment decisions for lower-risk myelodysplastic syndromes across practice settings
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Myelodysplastic Syndromes (MDS)
Curing the Incurable: TP53 Mutated Myeloid Neoplasms
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Abstract The TP53 gene ensures genetic fidelity by regulating cell cycle kinetics and apoptosis. In myeloid neoplasms, TP53 mutation is witnessed in 13% of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Alterations in TP53 or its respective protein is…
Imetelstat
Who should not take RYTELO?
Before taking RYTELO, tell your healthcare provider about all your medical conditions, including if you:
Understanding Brain Fog, Chemo Brain, with Dr. Jorg Dietrich
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Living Well with Bone Marrow Failure
Managing Your Treatment
Presenter(s)
Jorg Dietrich, MD, PhD
In this webinar, Dr. Jorg Dietrich will discusses the diagnosis of brain fog/chemo brain and how patients can manage this symptom of disease and its treatments.
Advances in Transplant and GVHD with Dr. Corey Cutler
Topic(s)
Bone Marrow Transplant
Presenter(s)
Corey Cutler, MD, MPH, FRCPC
In this webinar, Dr. Corey Cutler discusses advances in transplant and treating GVHD, or Graft Versus Host Disease.
IHC Testing Could Serve as Surrogate to NGS for Early Detection of TP53-Mutant MDS/AML
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Immunohistochemistry (IHC) could represent a biomarker for the early detection of TP53 mutations and for the prediction of a TP53 allelic state in patients with myelodysplastic neoplasms (MDS) and acute myeloid leukemia (AML), according to data from an observational trial…
A clinical guide to TP53 mutations in myeloid neoplasms
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TP53 mutations are found in 10-15% of myeloid neoplasms and are one of its most important prognostic factors. Emerging data show that TP53 mutational allele status is a key determinant of clinical outcomes, with multi-hit TP53 mutant myeloid neoplasms having a very poor prognosis…
Impaired cytotoxic function and exhausted phenotype of natural killer cells in VEXAS syndrome
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Key Points NK cells phenotyping reveals impaired cytotoxicity, chronic activation and exhaustion in VEXAS syndrome. Decreased circulating NK cells were independently associated with an increased risk of severe infections in VEXAS syndrome. VEXAS (vacuoles, E1 enzyme, X-linked…
Clinical Study on Targeted Drug Expands Treatment Options for Myelodysplastic Syndrome
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Their research led to the 2022 approval of olutasidenib for certain patients with IDH1-mutant AML, which occurs in about 10% of AML. After that success, Dr. Watts and his team began to focus closely on testing the drug in MDS, a related condition that often progresses to AML. IDH…
Combo eprenetapopt plus azacitidine is well-tolerated in TP53-mutated MDS and AML
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A phase 2 study found that eprenetapopt plus azacitidine induced responses in patients with TP53-mutated myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). This combination may be an opportune bridge to transplantation, according to David A. Sallman, MD, of the…