Key Points: Many patients and caregivers associate early palliative care (EPC) with hospice or death, a misperception that may persist even after gaining a better understanding of the role of EPC and may prevent them from experiencing the benefits of EPC. Cultural or religious…
Abstract Allogeneic hematopoietic cell transplantation (ASCT) is the only curative option for patients with myelodysplastic syndromes (MDS), but whether cytoreductive pretreatment and molecular “downstaging” according to the IPSS-M improves outcomes remains unclear. We…
ABSTRACT Allogeneic hematopoietic cell transplantation (allo-HCT) is an effective treatment for patients with high-risk hematologic malignancies. Over the last decade, gut microbiota composition during allo-HCT has been associated with patients' outcomes. Treatment-related…
In this issue of Blood, Muffly et al1 demonstrate in a phase 1 trial the feasibility and safety of CD117-targeted, precision preconditioning for allogeneic hematopoietic cell transplantation (allo-HCT) in acute myeloid leukemia (AML) and myelodysplastic neoplasia (MDS). Almost 70…
Myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML) are clonal myeloid neoplasms shaped by genetic lesions and immune dysregulation, both of which contribute to disease progression and poor outcomes. Existing prognostic systems, such as IPSS-R and IPSS-M, do not incorporate immune alterations. We assessed the biological and clinical relevance of an immune dysfunction signature (IDS) across multi-center MDS and CMML cohorts. IDS scores, derived from bulk transcriptomic data, were significantly associated with inferior leukemia-free and overall survival.
Risk stratification in myelodysplastic syndromes myelodysplastic syndromes:
Patients at risk for progression from myeloid precursor states (idiopathic cytopenia cytopenia: (sie-tuh-PEE-nee-uh) A shortage of one or more blood cell types. Also called a low blood count.
Dr. Reshma Ramlal is a hematologist-oncologist at the H. Lee Moffitt Cancer Center and Research Institute in Tampa, Florida. She specializes in bone marrow transplantation and cellular immunotherapy, with a clinical and research focus on allogeneic transplantation for myeloid malignancies, including acute myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms. She is particularly recognized for advancing safe and effective transplantation in the elderly population, offering individualized treatment plans that emphasize both survival and quality of life. In her clinical
