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A 30-gene classifier distinguishes low-risk MDS HSPCs from healthy HSPCs

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Highlights • Single-cell RNA-sequencing performed on 16 lower-risk myelodysplastic syndrome (LR-MDS) bone marrow-derived mononuclear cells (BMMCs) • A 30-gene signature distinguishes LR-MDS hematopoietic stem and progenitor cells (HSPCs) from Healthy HSPCs • Vesicular trafficking…

Cyclophosphamide and Cyclosporin for GVHD Prevention

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Curtis et al. (July 17 issue)1 report evidence of longer graft-versus-host disease (GVHD)–free, relapse-free survival with post-transplantation cyclophosphamide–based prophylaxis than with cyclosporin–methotrexate among patients receiving a stem-cell transplant from a matched…

Azacitidine as therapy for VEXAS syndrome

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How should patients with VEXAS (an acronym for vacuoles [in myeloid and erythroid precursors], E1 enzyme, X-linked, autoinflammatory, somatic) syndrome be treated? Until now, we have only had case reports and small series to guide us. In this issue of Blood, Jachiet and…

Jeremy A. Meier, MD, PhD

Institution
University of North Carolina at Chapel Hill School of Medicine
About
As a physician scientist Dr. Meier always had a passion for integrating patient care with research dedicated to improving cancer treatments. Clinically He is specialized in the management of patients with hematologic malignancies who are undergoing stem cell transplantation or receiving other cellular therapies, like CAR T cells. Dr. Meier research is focused on better understanding how to fully engage the immune system in its fight against cancer. He is studying how extracellular signals in the tumor microenvironment regulate the function of immune cells with a particular interest in
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