Order Patient Educational Materials
AAMDSIF provides educational materials for patients and healthcare professionals written in plain language and reviewed by highly respected and recognized medical doctors who are experts in bone marrow failure
patient
Study Connects Agent Orange Exposure to Earlier and More Severe Cases of Myelodysplastic Syndrome
Original Publication Date
Article Source
External Web Content
Summary Many veterans and doctors have long questioned whether Agent Orange (AO) exposure during the Vietnam War contributed to cases of myelodysplastic syndrome (MDS), a type of blood cancer. The contaminated chemical is linked to several cancers, but a link to MDS was unclear…
Outpatient Low-Dose Venetoclax-Azacitidine vs. Intensive Therapy in Newly Diagnosed AML in Resource-Limited Settings
Original Publication Date
Article Source
External Web Content
Key points Outpatient low-dose VenAza plus itraconazole reduced early mortality and hospitalizations while maintaining treatment efficacy. VenAza offers a safer, cost-effective alternative to intensive chemotherapy in newly diagnosed AML. Abstract Acute myeloid leukemia (AML)…
Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia
Original Publication Date
Article Source
External Web Content
Highlights Heme biosynthesis enzymes are variably suppressed in AML Heme levels are linked with altered leukemic transcriptional programs via BACH1 Heme biosynthesis is a selective dependency in AML, both in vitro and in vivo Heme starvation disrupts complex IV, inducing copper…
Inflammatory stromal and T cells mediate human bone marrow niche remodeling in clonal hematopoiesis and myelodysplasia
Original Publication Date
Article Source
External Web Content
Abstract Somatic mutations in hematopoietic stem/progenitor cells (HSPCs) can lead to clonal hematopoiesis of indeterminate potential (CHIP) and progression to myelodysplastic syndromes (MDS). Using single-cell and anatomical profiling of a large cohort of human bone marrow (BM)…
Rapid clonal selection within early hematopoietic cell compartments presages outcome to ivosidenib combination therapy
Original Publication Date
Article Source
External Web Content
Key Points Ivosidenib, venetoclax ± azacitidine either rapidly selects evolved, resistant leukemic clones or eradicates leukemic clones. Resistant clones express RNA signatures of stemness, branched-chain amino acid metabolism, and menin targets. Subjects:Myeloid Neoplasia…
Understanding PNH Treatment Options
Summary of FDA-approved medicines for treating PNH and transplantation options.
Symptom Tracker
Form to record symptoms or reactions to treatment and medications that can be shared with health care providers
Platelet Transfusion Record
Form to keep track of platelet transfusions as part of aplastic anemia treatment.
My Healthcare Team
Chart to record medical professionals, pharmacy contacts, patient support organizations and others involved with your health care.