Newsstand | Page 13 | Aplastic Anemia & MDS International Foundation

Here's where you'll find a regularly updated, broad range of articles written by the AAMDSIF team, allied health organizations and news organizations. By staying well-informed, patients and families are practicing a form of self-support that will help them be more effective self-advocates when engaging with health care providers.


PACCT+ Patient Group Meets and Learns Together

Originally Published: 07/10/2017
On June 17, the AAMDSIF Patient Advisory Council on Clinical Trials (PACCT+) members met in Arlington, Virginia for the second orientation seminar, meeting fellow committee members and learning from two experts about clinical trial design and the state of current MDS research. By their selection and participation, PACCT+ participants are expected to become familiar with clinical science research to ensure their ability to provide informed feedback that would benefit a study’s design and impact. PACCT+ is a two-year demonstration project to develop and test a program to train patients in...

Approved: New blood cancer detection tool

Originally Published: 07/05/2017
ClearLLab multicolor reagents (T1, T2, B1, B2, M) gained approval from the Food and Drug Administration (FDA) to detect chronic leukemia, acute leukemia, non-Hodgkin lymphoma, multiple myeloma, myelodysplastic syndrome (MDS) and myeloproliferative neoplasms (MPN). This is the first approval the agency received for immunophenotyping on a flow cytometer. The approval was based on the effectiveness of the screening panel compared with alternative methods for the detection of leukemias and lymphomas in 279 samples at four independent clinical sites. Overall, findings from the ClearLLab reagents...

Senior citizens underrepresented in clinical trials

Originally Published: 06/29/2017
More than 60 percent of cancer patients are older adults — and that will rise to 70 percent by 2040.  Yet seniors continue to be underrepresented in clinical trials, making it difficult to assess how treatments are likely to help or harm them. The newest evidence of the problem comes from a Food and Drug Administration analysis, which found that only 25 percent of patients participating in cancer clinical trials were 65 and older. The analysis, which has not yet been published, was presented at the American Society of Clinical Oncology’s annual meeting in June. Clinical trials investigate...

Study shows good results for older transplant patients

Originally Published: 06/13/2017
Many hematologic malignancies most commonly affect older adults. For example, the median age at diagnosis of acute myeloid leukemia (AML) is about 65 years, while the median age at presentation of MDS is more than 70 years, and the risk of MDS and AML continues to rise with advancing age. Historically, the potentially curative option of allogeneic hematopoietic stem cell transplant (HSCT) was not offered to most adults over the age of 65 due to increased relapse risk, the high frequency of comorbid conditions that make transplant-associated conditioning and immunosuppression difficult to...

New data presented at ASCO on secondary MDS/AML

Originally Published: 06/05/2017
Cancer patients with secondary malignancies have limited access to data regarding the possibility of their myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), or both, being caused by the usage of certain chemotherapeutic agents that could possibly interfere with DNA. New data concludes, though, that the incidence of MDS and AML in ovarian and breast cancer patients was higher in patients exposed to DNA damaging agents. The data, presented at the 2017 American Society of Clinical Oncology (ASCO 2017) annual meeting in Chicago by Nicole Fulcher, et al, were gathered with the...

MDS Update - May 2017

Originally Published: 05/30/2017
MDS Update - May 2017

Aplastic Anemia Update - May 2017

Originally Published: 05/25/2017
Aplastic Anemia Update - May 2017

What you need to know about BMT reimbursement

Originally Published: 05/19/2017
The Centers for Medicare & Medicaid Services (CMS) issue the FY 2018 Inpatient Prospective Payment System proposed rule on April 14th. While we are disappointed that the proposed rule did not address allogeneic HCT cell acquisition, there are other significant changes that will impact your transplant center. 

Research in making blood stem cells in the lab advances

Originally Published: 05/18/2017
Researchers at Boston Children's Hospital have, for the first time, generated blood-forming stem cells in the lab using pluripotent stem cells, which can make virtually every cell type in the body. The advance, published today in the journal Nature, opens new avenues for research into the root causes of blood diseases and to creating immune-matched blood cells for treatment purposes, derived from patients' own cells. "We're tantalizingly close to generating bona fide human blood stem cells in a dish," says senior investigator George Daley, MD, PhD, who heads a research lab in Boston Children...

MDS patients in promising AML study on telomeres

Originally Published: 05/10/2017
Researchers said measuring DNA sections in cancer cells gave an "accurate indicator" of disease progression. Shorter DNA structures can leave chromosome ends exposed, accelerating cancer progression and drug resistance. The team believe the study could help doctors in choosing the most effective treatment for individual patients. Researchers from the university's School of Medicine said the tests can be used to predict the outcomes of patients with two different types of blood cancer - the bone marrow cancer myeloma and pre-leukaemia myelodysplastic syndromes (MDS). The latter is a bone...