Prednisone | Aplastic Anemia & MDS International Foundation Return to top.


Introductory image: March for Marrow participants

How does it work?

For PNH, it may be used to decrease hemolysis caused by PNH. It may make the complement system less active. Prednisone does not stop all hemolysis, however, and it does have a lot side effects, especially if taken for a long time. Currently, doctors disagree about whether it should be used by PNH patients.

For aplastic anemia it may be used to stop the effects of serum sickness after immunosuppressive therapy with ATG.

Prednisone may also increase counts of white blood cells and platelets in some bone marrow failure patients.

What are common side effects?

Some common side effects of Prednisone include:

  • sleep problems (insomnia)
  • mood changes
  • increased appetite
  • acne
  • increased sweating
  • dry or thinning skin
  • slow wound healing
  • headache, dizziness, spinning sensation
  • nausea, stomach pain

Most people who take prednisone for a long time use it only every other day. This schedule eases the most severe side effects of prednisone.


The data provided on Prednisone is for informational purposes only. It is not intended to be comprehensive or to substitute for professional medical advice. Always talk with your doctor or other qualified health provider about your condition and any drug or other treatment you are considering. Make sure you fully understand all side effects, risks and potential benefits associated with any drug or treatment. Never disregard professional medical advice or delay seeking it because of the information provided here. Although AAMDSIF strives to provide accurate and up-to-date information, it does not guarantee the accuracy or currency of this information.

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