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Integration of Cellular Therapy Jumpstarts Research Efforts in Acute Leukemias

With the goal of capitalizing on the efficacy observed with cellular therapies in acute leukemias, ongoing research efforts are underway to address unanswered questions regarding the role of transplant in conjunction with cellular therapy, optimal toxicity management, antigen escape, and methods to overcome myelosuppression and immunosuppression in these diseases, said Michael Grunwald, MD.

“If it’s the time, it’s the time”: Existential communication in naturally-occurring palliative care conversations with individuals with advanced cancer, their families, and clinicians

Highlights

  • We analyzed naturally-occurring inpatient palliative care conversations.
  • Existential communication is pervasive and varied in palliative care conversations
  • Patients, families, and clinicians talk about time, the self, and connectedness.
  • Findings help develop a lexicon for everyday existential communication.

(Article continues at link.)

COVID-19 vaccination for hematopoietic stem cell transplant patients

The SARS-CoV-2 pandemic has changed the world over the last year and impacted almost every part of our lives. In particular, patients with hematologic malignancies have been significantly affected by this crisis at every stage of their treatment. Delays in diagnosis and increased waiting times for transplants and therapy have become common occurrences. Patients with hematologic malignancies are also more likely to suffer from severe COVID-19, leading to a greater mortality rate.

Long‐term Results of Low‐intensity Chemotherapy with Clofarabine or Cladribine Combined with Low‐Dose Cytarabine Alternating with Decitabine in Older Patients with Newly Diagnosed Acute Myeloid Leukemia

Abstract
Background
The treatment of older patients with newly diagnosed

Traipsing Through Muddy Waters: A Critical Review of the Myelodysplastic Syndrome/Myeloproliferative Neoplasm (MDS/MPN) Overlap Syndromes

Author(s): 
Kuykendall AT, Tokumori FC, Komrokji RS
Primary Author: 
Kuykendall AT
Journal Title: 
Hematology/oncology clinics of North America
Original Publication Date: 
Apr 2021

Myelodysplastic syndrome/Myeloproliferative neoplasms (MDS/MPNs) are molecularly complex, clinically heterogeneous diseases that exhibit proliferative and dysplastic features. Diagnostic criteria use clinical, pathologic, and genomic features to distinguish between disease entities, though considerable clinical and genetic overlap persists. MDS/MPNs are associated with a poor prognosis, save for MDS/MPN with ring sideroblasts and thrombocytosis, which can behave more indolently.