CC-486—the oral formulation of azacitidine—significantly improved RBC transfusion independence (RBC-TI) rates and induced durable bilineage improvements in patients with lower-risk

Key Points
Mesothelin is aberrantly expressed in over one third of childhood and young adult AML and not expressed on normal hematopoietic cells.

Mesothelin is successfully targeted in vitro and in xenograft models of MSLN+ AML with ADCs.

Abstract

With the goal of capitalizing on the efficacy observed with cellular therapies in acute leukemias, ongoing research efforts are underway to address unanswered questions regarding the role of transplant in conjunction with cellular therapy, optimal toxicity management, antigen escape, and methods to overcome myelosuppression and immunosuppression in these diseases, said Michael Grunwald, MD.

Highlights

• We analyzed naturally-occurring inpatient palliative care conversations.
• Existential communication is pervasive and varied in palliative care conversations
• Patients, families, and clinicians talk about time, the self, and connectedness.
• Findings help develop a lexicon for everyday existential communication.

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Key Points
Donor-derived T cells with native specificity for multiple myeloid leukemia antigens can be expanded ex vivo.

Infusion of mLSTs after HCT is well tolerated and produces antileukemia effects.

The SARS-CoV-2 pandemic has changed the world over the last year and impacted almost every part of our lives. In particular, patients with hematologic malignancies have been significantly affected by this crisis at every stage of their treatment. Delays in diagnosis and increased waiting times for transplants and therapy have become common occurrences. Patients with hematologic malignancies are also more likely to suffer from severe COVID-19, leading to a greater mortality rate.

ABSTRACT

Meningioma-1 (MN1) is a protein whose overexpression has been linked to

Abstract
Background
The treatment of older patients with newly diagnosed