Acute Myeloid Leukemia (AML)

Researchers Uncover How MN1 Overexpression Causes AML

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Meningioma-1 (MN1) is a protein whose overexpression has been linked to acute myeloid leukemia (AML) and brain tumors, and 70% to 80% of AML patients with high overexpression of MN1 die within two years. Yet the mechanism by which MN1 causes these diseases has largely remained a…

RARA Agonist Plus Azacitidine Shows Encouraging Activity in Relapsed/Refractory AML

Original Publication Date
Article Source
External Web Content
The novel agentSY-1425 combined with azacitidine appears to be active in retinoic acid receptor alpha (RARA) superenhancer–positive newly diagnosed and relapsed or refractory acute myeloid leukemia (AML), according to the results of a phase II trial presented at the 2020 American…

Nathan Punwani, MD, MPH

Institution
Cedars-Sinai
Physician Status
accepting new patients
Primary Disease Area of Focus
Acute Myeloid Leukemia (AML)
Aplastic Anemia
Graft Versus Host Disease (GVHD)
Myelodysplastic Syndromes (MDS)
About
Dr. Punwani is a hematologist/oncologist with the Blood and Marrow Transplant Program at the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai. He earned his BA from Lehigh University, an MPH in Health Care Management & Policy from Harvard School of Public Health and his MD from Drexel University College of Medicine. He did his Internal Medicine Residency at George Washington Unviersity Hospital and his Fellowships in Hematology and Oncology at the University of Southern California. Dr. Punwani is board certified in Internal Medicine and is both researcher and clinician with more

Ivana Gojo, MD

Institution
Johns Hopkins Sidney Kimmel Cancer Center
Physician Status
accepting new patients
Primary Disease Area of Focus
Acute Myeloid Leukemia (AML)
Chronic Lymphocytic Leukemia (CLL)
About
Dr. Ivana Gojo is a Hematologist/Oncologist in Baltimore. Her clinical focus is on diagnosis and management of patients with acute leukemias (AML, ALL) and other myeloid malignancies (MDS, MPNs, CML), with emphasis on the development of novel therapeutic approaches for these diseases. She is nationally and internationally recognized expert in clinical translation of novel therapeutics for acute leukemias and principal investigator on multiple multi-center investigator-initiated studies. Dr. Gojo joined the Johns Hopkins faculty in 2012 as the Co-Director of Leukemia Drug Development Program

Catherine Chittick, RN, BSN

Institution
Massachusetts General Hospital Cancer Center
Physician Status
available for consultation
Primary Disease Area of Focus
Acute Myeloid Leukemia (AML)
Myelodysplastic Syndromes (MDS)
About
Catherine Chittick, RN, BSN is an oncology nurse at the Massachusetts General Hospital (MGH), where she has been employed for five years since the start of her career. After graduating from Sacred Heart University (Fairfield, CT) School of Nursing in 2015, Catherine joined the nursing profession as a registered nurse at the MGH as part of the eCare Nursing Residency program for new graduates. She has both outpatient and inpatient experience, working first in an outpatient infusion nurse caring for leukemia and bone marrow transplant patients before moving inpatient to care for patients with

Jenna Moran, MSN, FNP-BC

Institution
Massachusetts General Hospital Cancer Center
Physician Status
available for consultation
Primary Disease Area of Focus
Acute Myeloid Leukemia (AML)
Myelodysplastic Syndromes (MDS)
About
Jenna Moran, MSN, FNP-BC, is an oncology nurse practitioner with the Leukemia department at the Massachusetts General Hospital Cancer Center in Boston, MA. She has experience in both the ambulatory and inpatient care settings. Her current areas of clinical focus include acute myeloid leukemia, acute lymphocytic leukemia, chronic myeloid leukemia and myelodysplastic syndrome. She has worked as clinical faculty at Simmons College as an instructor for medical surgical nursing. Additionally, she has worked as a global health nurse educator providing bone marrow transplant education and training to

Aura Ramos, RN, BSN

Institution
Massachusetts General Hospital Cancer Center
Physician Status
available for consultation
Primary Disease Area of Focus
Acute Myeloid Leukemia (AML)
Myelodysplastic Syndromes (MDS)
About
Aura Ramos, RN, BSN, is a leukemia research nurse at the Massachusetts General Hospital Cancer Center in Boston for the past 6 years. Aura has over 16 years of nursing experience caring for oncology patients in the ambulatory and inpatient setting. Prior to becoming a research nurse, she worked as a staff nurse on the leukemia and bone marrow transplant unit. She had the opportunity to travel to Dhaka, Bangladesh and educate nurses on caring for bone marrow transplant and leukemia patients. As a research nurse, she continues to educate staff on the administration of new research oral and

SY-1425

SY-1425: SY-1425 is a selective retinoic acid receptor alpha (RARα) agonist for genomically defined subsets of patients whose disease is characterized by the overexpression of the RARA gene.

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