Myelodysplastic Syndromes (MDS)

Azacitidine as therapy for VEXAS syndrome

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How should patients with VEXAS (an acronym for vacuoles [in myeloid and erythroid precursors], E1 enzyme, X-linked, autoinflammatory, somatic) syndrome be treated? Until now, we have only had case reports and small series to guide us. In this issue of Blood, Jachiet and…

Germline and somatic genetic landscape of pediatric myelodysplastic syndromes

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Abstract Pediatric myelodysplastic syndromes (MDS) represent a rare group of clonal hematopoietic stem cell disorders accounting for approximately 5% of pediatric hematologic malignancies. They are characterized by ineffective hematopoiesis, cytopenia, and dysplastic changes in…

Brandi Reeves, MD

Institution
University of North Carolina at Chapel Hill School of Medicine
Physician Status
accepting new patients
Primary Disease Area of Focus
Aplastic Anemia
Myelodysplastic Syndromes (MDS)
Myeloproliferative Neoplasms (MPN)
Paroxysmal Nocturnal Hemoglobinuria (PNH)
About
I am a physician-scientist specializing in myeloproliferative neoplasms (MPN), bone marrow failure syndromes, lower risk myelodysplastic syndromes (MDS), and clonal hematopoiesis. I lead our MPN program, which was established in 2019 and provides clinical and research expertise for MPN patients. My research primarily focuses on mechanisms of thrombosis in MPN, with a goal to improve MPN care by individualizing thrombosis risk stratification and by finding better treatments to prevent thrombosis. I am also dedicated to training the next generation of physicians and am involved in medical

Jose C. Martinez, MD, PhD

Institution
University of North Carolina at Chapel Hill School of Medicine
Physician Status
accepting new patients
Primary Disease Area of Focus
Acute Myeloid Leukemia (AML)
Aplastic Anemia
Myelodysplastic Syndromes (MDS)
Myeloproliferative Neoplasms (MPN)
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Pediatric
About
I am a physician-scientist who sees patients in clinic with disorders of clonal hematopoiesis and myeloid cancers, including acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). My clinical and research interests focus on RNA regulation in hematologic malignancies. Specifically, I investigate how mutations in splicing factors affect RNA processing and contribute to disease progression. These genetic mutations can occur at any stage of life, leading to complex disorders that are often challenging to diagnose and treat. In the laboratory, we utilize advanced genomic technologies

Patient Education Strategies for Patients with Bone Marrow Failure

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Topic(s)
Related Bone Marrow Failure Diseases and Malignancies
Bone marrow failure disorders are challenging to understand and explain. It can be overwhelming to be diagnosed with a rare disease like aplastic anemia, MDS or PNH, so it’s important for patients to learn about their disease, treatment options, and support for their journey…

Lacey Williams, MD

Institution
University of North Carolina School of Medicine
Physician Status
accepting new patients
Primary Disease Area of Focus
Acute Myeloid Leukemia (AML)
Myelodysplastic Syndromes (MDS)
About
Dr. Lacey Williams specializes in the care of patients with acute leukemias and myeloid malignancies, with interests in germline syndromes and improving outcomes for minority populations. She chose the field of oncology for the combination of close patient relationships and opportunities for scientific advances in the field. She aims to support patients during their treatment journey with the most helpful information and clinical resources

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