Special Issues for People with Aplastic Anemia

Because you have aplastic anemia: (ay-PLASS-tik uh-NEE_mee-uh) A rare and serious condition in which the bone marrow fails to make enough blood cells - red blood cells, white blood cells, and platelets. The term aplastic is a Greek word meaning not to form. Anemia is a condition that happens when red blood cell count is low. Most… , everyday events can be more risky for you than for healthy people. Here are some examples.

Airplane Travel and High Altitudes

The higher you go above sea level, the less oxygen there is. If you have aplastic anemia, flying in an airplane or going up high in the mountains may cause a shortage of oxygen. It may also cause chest pain. Changes in cabin pressure can cause bleeding inside the ear if platelets are very low. The recirculated air may increase risk of viral infection.

Before you do either of these things, it's a good idea to:

  • Get a red blood cell: The most numerous type of blood cell in healthy people. Red blood cells contain hemoglobin, a protein that picks up oxygen in the lungs and brings it to cells in all parts of the body. Also called erythrocyte, RBC. count and a platelet: The smallest type of blood cell. Platelets help the blood to clot and stop bleeding. Also called a thrombocyte. count
  • Get transfusions if necessary
  • Ask your doctor if it is safe

Dental Care

Brush and floss your teeth and get regular dental care to reduce the risk of infections in your mouth and throat. If a dental procedure is needed, talk with your treating physician first as you may need an antibiotic: (an-tee-by-AH-tik) A medicine that fights bacterial infections. When a person with bone marrow failure does not have enough neutrophils, the white blood cells that fight infection, antibiotics may help to prevent and fight infection. or other treatments before the procedure.

Physical Activity

Talk with your doctor about what types and amounts of physical activity are safe for you. You may want to avoid activities that cause chest pain or shortness of breath. You also may want to stay away from activities that could result in injuries and bleeding, such as contact sports.

Pregnancy and Aplastic Anemia

Pregnancy is possible for women who have been treated for aplastic anemia. But it carries some significant risks for both mother and child.

There is limited research on pregnancy and aplastic anemia. However, one study done in 2002 showed that 19 percent of women had a relapse of aplastic anemia during pregnancy. This means that their blood counts went down. Some women also needed blood transfusions: A blood transfusion is a safe and common procedure. Most people who have a bone marrow failure disease like aplastic anemia, MDS or PNH will receive at least one blood transfusion. When you receive a blood transfusion, parts of blood from a donor are put into your bloodstream. This can help some… during childbirth.

This study also showed that you may have an increased risk of problems during pregnancy if:

  • You have a low platelet count.
  • You also have PNH.

If you have had aplastic anemia and are pregnant or want to get pregnant, find an aplastic anemia specialist and an obstetrician (OB) who specializes in high-risk births. Every person and every pregnancy is different. Make sure you talk with the specialist about your specific case and understand all the risks.

Surgery

Surgery can also be risky for people with aplastic anemia. Surgery can cause serious bleeding in people with a low platelet count. Platelet transfusions may be needed before surgery. The risk for serious infections is also higher.

If you do have surgery, it's a good idea to make sure your aplastic anemia specialist talks with your surgeon.

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