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COVID-19 vaccination for hematopoietic stem cell transplant patients

The SARS-CoV-2 pandemic has changed the world over the last year and impacted almost every part of our lives. In particular, patients with hematologic malignancies have been significantly affected by this crisis at every stage of their treatment. Delays in diagnosis and increased waiting times for transplants and therapy have become common occurrences. Patients with hematologic malignancies are also more likely to suffer from severe COVID-19, leading to a greater mortality rate.

Long‐term Results of Low‐intensity Chemotherapy with Clofarabine or Cladribine Combined with Low‐Dose Cytarabine Alternating with Decitabine in Older Patients with Newly Diagnosed Acute Myeloid Leukemia

Abstract
Background
The treatment of older patients with newly diagnosed

Traipsing Through Muddy Waters: A Critical Review of the Myelodysplastic Syndrome/Myeloproliferative Neoplasm (MDS/MPN) Overlap Syndromes

Author(s): 
Kuykendall AT, Tokumori FC, Komrokji RS
Primary Author: 
Kuykendall AT
Journal Title: 
Hematology/oncology clinics of North America
Original Publication Date: 
Apr 2021

Myelodysplastic syndrome/Myeloproliferative neoplasms (MDS/MPNs) are molecularly complex, clinically heterogeneous diseases that exhibit proliferative and dysplastic features. Diagnostic criteria use clinical, pathologic, and genomic features to distinguish between disease entities, though considerable clinical and genetic overlap persists. MDS/MPNs are associated with a poor prognosis, save for MDS/MPN with ring sideroblasts and thrombocytosis, which can behave more indolently.

Bone Marrow Disease(s): 

Palliative Medicine in Myelodysplastic Syndromes: Patients and Caregivers - A Qualitative Study

Author(s): 
Desai AV, Klimek VM, Wan PJ, Heinberg A, Anderson KL, Bernal C, Nelson JE
Primary Author: 
Desai AV
Journal Title: 
BMJ Supportive & Palliative Care
Original Publication Date: 
Apr 2021

Objectives: Evidence-based guidelines call for integration of palliative care within oncology from diagnosis. Misperceptions about palliative care have impeded implementation. Prior research has not examined perceptions about 'palliative care' versus '

Bone Marrow Disease(s): 

Epigenetic Aging and Hematopoietic Cell Transplantation in Patients With Severe Aplastic Anemia

Author(s): 
Alsaggaf R, Katta S, Wang T, Hicks BD, Zhu B, Spellman SR, Lee SJ, Horvath S, Gadalla SM
Primary Author: 
Alsaggaf R
Journal Title: 
Transplantation and Cellular Therapy
Original Publication Date: 
Apr 2021

Cellular aging in hematopoietic cell transplantation (HCT) is important in the context of immune reconstitution and age-related complications. Recently, several DNA-methylation (DNAm)-based biomarkers of aging known as "epigenetic clocks" have been introduced as novel tools to predict cellular age.

Bone Marrow Disease(s): 

Eltrombopag in children with severe aplastic anemia

Author(s): 
Lesmana H, Jacobs T, Boals M, Gray N, Lewis S, Ding J, Kang G, Hale M, Weiss M, Reiss U, Wang W, Wlodarski M
Primary Author: 
Lesmana H
Journal Title: 
Pediatric Blood & Cancer
Original Publication Date: 
Apr 2021

Background: Immunosuppressive therapy with horse antithymocyte globulin and cyclosporine currently remains the standard therapy for children with severe

Bone Marrow Disease(s):