paroxysmal nocturnal hemoglobinuria (PNH) | Page 15 | Aplastic Anemia and MDS International Foundation

paroxysmal nocturnal hemoglobinuria (PNH)

Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria

Author(s): 
Shen W, Clemente MJ, Hosono N, Yoshida K, Przychodzen B, Yoshizato T, Shiraishi Y, Miyano S, Ogawa S, Maciejewski JP, Makishima H
Primary Author: 
Shen W
Journal Title: 
J Clin Invest
Original Publication Date: 
Sep 2014

Clinical Trials and Children

If your child has a bone marrow failure disease and you are considering a clinical trial, there are important things you need to know. For example, clinical trials in children, by law, must provide the potential for at least a minimal benefit. This section provides information and guidelines to help you make an informed choice about clinical trial participation for your child.

Complement in paroxysmal nocturnal hemoglobinuria: exploiting our current knowledge to improve the treatment landscape

Author(s): 
Mastellos DC, Ricklin D, Yancopoulou D, Risitano A, Lambris JD
Primary Author: 
Mastellos DC
Journal Title: 
Expert Rev Hematol
Original Publication Date: 
Sep 2014

Stephen King: Patient, Educator, and Volunteer

Person's Name: 
Stephen King

A PNH survivor for more than 25 years, Stephen King speaks about his life as a patient and an advocate in both formal and informal roles -- and offers advice for newly diagnosed PNH patients.

 “I’m an engineer with a problem-solving orientation,” says the medical software manager from Atlanta, Georgia. “After my diagnosis, I thought, now that you know what it is, let’s fix it. It took a little time to sink in that there was no quick fix, and I had to learn more about it.”

Content source: 

Paroxysmal nocturnal hemoglobinuria clones in children with acquired aplastic anemia: a multicentre study

Author(s): 
Timeus F, Crescenzio N, Longoni D, Doria A, Foglia L, Pagliano S, Vallero S, Decimi V, Svahn J, Palumbo G, Ruggiero A, Martire B, Pillon M, Marra N, Dufour C, Ramenghi U, Saracco P
Primary Author: 
Timeus F
Journal Title: 
PLoS One
Original Publication Date: 
Jul 2014

A multicentre study evaluating the presence of glycosil phosphatidyl-inositol (GPI)-negative populations was performed in 85