Reduced Intensity Double Umbilical Cord Blood Transplantation | Aplastic Anemia and MDS International Foundation

Clinical Trial: NCT01408563

Reduced Intensity Double Umbilical Cord Blood Transplantation
For more details on this clinical trial, including contact information, please see this trial’s listing on

Subjects will receive their transplants as in-patients.

  • IV-Catheter

    • one or two IV catheters will be placed on the day of hospital admission
  • Conditioning

    • Fludarabine IV six days before transplant (days -7, -6, -5. -4, -3, -2)
    • Melphalan IV (day -1)
    • Total body radiation on day 0 (same day as transplant)
  • Immunosuppressive Therapy

    • Tacrolimus and sirolimus beginning day -3, daily for 6-9 months post-transplant. Given IV as in-patient, orally as out-patient
  • Infusion of Cord Blood units

    • 2 cord blood units IV on Day 0 Routine post-transplant supportive care will be provided
Study Date: 
Tue, 08/02/2011 to Mon, 08/01/2016
Bone Marrow Disease(s): 
aplastic anemia
Associated Drug(s): 
Drug: Fludarabine 30 mg/m2/day IV x 6 days Other Name: Fludara Drug: Melphalan 100 mg/m2/day IV x 1 day Radiation: Total Body Radiation 200 cGy on Day 0 Biological: Cord Blood 2 cord blood units IV