BCX9930 for the Treatment of PNH in Subjects Not Receiving Other Complement Inhibitor Therapy (REDEEM-2 Trial) | Aplastic Anemia & MDS International Foundation Return to top.

ClinicalTrials.gov Identifier:

NCT05116787

Contact Info

BioCryst Pharmaceuticals, Inc.

BCX9930clinicaltrials@biocryst.com

+1 (844) 273-2328 (toll free)

Dates

Start: October 2021
End: August 2023

Official Title

BCX9930 for the Treatment of PNH in Subjects Not Receiving Other Complement Inhibitor Therapy (REDEEM-2 Trial)

Purpose

The purpose of this study is to evaluate the efficacy and safety of BCX9930 as a treatment for PNH in adult patients who are not currently being treated with a complement inhibitor. BCX9930 is a Factor D inhibitor administered orally (by mouth). The study will recruit approximately 57 patients worldwide and each individual’s participation will last approximately 1 year. The study will be run in two parts. In part 1, participants will be randomly assigned in a 2:1 ratio to either BCX9930 or placebo for 12 weeks. Participants will not know which treatment they are receiving in part 1. In part 2, all participants will receive BCX9930. Participants assigned to placebo initially will be switched to BCX9930 after Week 12. Patients assigned to BCX9930 initially will continue BCX9930 in part 2. At the end of the study (Week 52), participants who are experiencing benefit from BCX9930 treatment may be allowed to continue BCX9930 treatment in a long-term follow-up study.

BCX9930 for the Treatment of PNH in Subjects Not Receiving Other Complement Inhibitor Therapy (REDEEM-2 Trial)

Clinical Trial: NCT05116787

Instructions

If you are interested in learning more about your possible participation in this clinical trial, please complete the form. Your information will be forwarded directly to the sponsoring company.

Status: 
Active, not recruiting
Associated Drug(s): 
Phase: 
Phase 2
Gender: 
Female
Male
Age Group: 
18 years and older
Accepts Healthy Volunteers: 
No
Inclusion Criteria: 
  • Body weight >= 40 kg (88 lb).
  • Documented diagnosis of PNH confirmed by flow cytometry (white blood cell clone size >= 10%).
  • Either no prior complement inhibitor treatment or no treatment within past 12 months.
  • Hemoglobin <= 10.5 g/dL and LDH >= 2 x normal at screening.
  • Either current with or willing to be vaccinated against Neisseria meningitidis and other bacterial infections as needed.
  • If a woman of childbearing potential or a male with a female partner of childbearing potential, willing to practice appropriate contraception to avoid pregnancy throughout the study and at least 30 (women) or 90 (men) days after the study.
  • Willing and able to comply with all study visits and procedures, including twice daily dosing with study treatment. Able to provide written informed consent to participate.
Exclusion Criteria: 
  • Prior diagnosis of hereditary complement deficiency.
  • History of or a current candidate for bone marrow or other transplant.
  • Ongoing or recent history (<= 30 days) of clinically relevant cardio or cerebrovascular disease or a clinically significant abnormal electrocardiogram (ECG) tracing at screening.
  • Ongoing or recent history (<= 5 years) of malignancy (cancer) (some exceptions apply).
  • Ongoing or recent history of (<= 14 days) serious bacterial, fungal, or viral infection.
  • Ongoing or recent (<= 30 days) participation in a clinical trial with an investigational (experimental) therapy.
  • Treatment with ATG (anti-thymocyte globulin) in past 6 months.
  • Recently started treatment (<= 28 days) with a red blood cell or platelet growth factor, danazol, or iron supplementation regimen at an unstable dose.
  • Use of any other medication prohibited by the study protocol.
  • Elevated liver function test or bilirubin levels at screening that is not explained by hemolysis or Gilbert’s syndrome.
  • HIV or hepatitis B or C infection (unless infection is well-controlled on antiviral therapy).
  • Positive drugs of abuse screen (unless supported by prescription).
  • Known severe sensitivity to drugs (eg, prior anaphylactic reaction).
  • Pregnant or breastfeeding, or intending to get pregnant during the study.
  • Any other clinically significant medical or psychiatric condition that could interfere with study participation or increase the risk of study participation.
  • The above list is not intended to be exhaustive; each individual’s participation must be confirmed by the responsible physician conducting the study.

 

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