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  1. Fludarabine Phosphate, Cyclophosphamide, and Total-Body Irradiation Followed by Donor Bone Marrow Transplant and Cyclophosphamide, Mycophenolate Mofetil, Tacrolimus, and Sirolimus in Treating Patients With Primary Immunodeficiency Disorders or Noncancerou

    ... disorders who do not have an HLA-matched related or unrelated donor . SECONDARY OBJECTIVES: I. Determine whether nonmyeloablative ...

    Clinical Trial last updated 04/26/2016 - 2:09pm.

  2. T Cell Depletion for Recipients of HLA Haploidentical Related Donor Stem Cell Grafts (MOHEL)

    ... Unfortunately, there is not a perfectly matched stem cell donor (like a sister or brother) and the subject's disease is considered ... In recipients of mismatched family member or matched unrelated donor stem cell transplants, there is a greater risk of GVHD so ...

    Clinical Trial last updated 04/28/2016 - 12:15pm.

  3. First-in Human Clinical Transplant Trial for Severe Aplastic Anemia

    ... for patients who lack an HLA identical sibling or unrelated donors. This work that we began aimed at helping patients that did not have an HLA matched donor started about 12 years ago. This is when we tried to come up with a ...

    Interview last updated 10/04/2017 - 1:36pm.

  4. Transplantation of Partially Mismatched Related or Matched Unrelated Bone Marrow for Patients With Refractory Severe Aplastic Anemia

    ... or ethnic background. Prior transfusions from selected donor (as this could have cause recipient alloimmunization against the donor) Women of childbearing potential who currently are pregnant (HCG+) or ...

    Clinical Trial last updated 06/06/2016 - 2:42pm.

  5. Overview of stem cell transplantation for aplastic anemia

    ... stem cells taken from another person, known as the donor source or source of the graft. The donor can be the patient’s brother ... patient does not have a matched sibling or related donor, an unrelated individual that shares important genetic similarities with the ...

    Research Review last updated 05/02/2016 - 9:31am.

  6. HLA-Compatible Related or Unrelated Donors With CD34+ Enriched, T-cell Depleted Peripheral Blood Stem Cells Isolated by the CliniMACS System in the Treatment of Patients With Hematologic Malignancies

    ... and must sign an informed consent form.   Donor Inclusion Criteria: Each donor must meet criteria outlined by institutional guidelines Donor should ...

    Clinical Trial last updated 04/29/2016 - 3:18pm.

  7. Donor Lymphocyte Infusion (DLI) of T-cells Genetically Modified With iCasp9 Suicide Gene

    ... designed to block participant's body's ability to reject the donor's stem cells . Researchers also want to learn if giving AP1903 ... -matched for HLA-A, -B, C and DR matched or, b. Matched Unrelated Donor (MUD), 8/8 HLA-matched for HLA A, B, C and DRB1 using ...

    Clinical Trial last updated 06/06/2016 - 12:41pm.

  8. Briana Donis

    ... National Bone Marrow Registry came up with five unrelated donor matches. “A lot of people aren't lucky enough to have even one ...

    "Like You" Patient Story last updated 04/28/2017 - 1:56pm.

  9. Bone Marrow Transplant

    ... cell transplants. A transplant may use cells taken from a donor or from the patient: Autologous transplants use a patient's ... donor. These might come from a sibling, or a matched unrelated donor (MUD). The donor's tissue type must be a suitable match ...

    Topic section last updated 03/29/2016 - 7:27pm.

  10. Calcineurin Inhibitor-Free Interventions for Prevention of Graft-versus-Host Disease (BMT CTN 1301)

    ... in Table 2.4) Patients must have a related or unrelated donor as follows: Related donor must be an 8/8 match for human ...

    Clinical Trial last updated 06/06/2016 - 1:36pm.